Part I: Introduction
1. The Past, Present and Future of Chemical Risk Assessment
Alice Limonciel
Part II: Systemic Organ Toxicity
2. In Vitro Systems for Hepatotoxicity Testing
Jan G. Hengstler, Seddik Hammad, Ahmed Ghallab, Raymond Reif and Patricio Godoy
3. In Vitro Methods for Cardiotoxicity Testing
Vaibhav Shinde, Umesh Chaudhari, Isaia Sotiriadou, Jürgen Hescheler and Agapios Sachinidis
4. Renal Cell Culture
Paul Jennings, Lydia Aschauer, Anja Wilmes and Gerhard Gstraunthaler
5. Cellular Models for In Vitro Lung Toxicology
Oliver H. Wittekindt
Part III: Neurotoxicity
6. In Vitro Developmental Neurotoxicity Testing: Relevant Models and Endpoints
Anna Bal-Price and Helena T. Hogberg
7. Blood Brain Barrier In Vitro Models and Their Applications in Toxicology
Anaelle Fabulas-Da Costa, Christophe Landry, Lucie Dehouck, Emmanuel Sevin, Marie-Pierre Dehouck, Roméo Cecchelli and Maxime Culot
Part IV: Sensory Organ Models
8. Ocular Toxicity
Chantra Eskes, Erwin van Vliet, Michael Schäffer and Valérie Zuang
9. In Vitro Models for Ototoxic Research
Jochen Schacht and Michael G. Leitner
Part V: Other Organs and Aspects
10. Dermal Toxicity: Skin Sensitization
David Basketter and Silvia Casati
11. Immunotoxicity
Thomas Hartung
12. Reproductive Toxicity
Giovanna Lazzari and Cesare Galli
13. Evaluating Endocrine Disruption In Vitro
Patrick J. Devine
14. Current and Emerging In Vitro Methods for Genotoxicity and Carcinogenicity
Federica Madia, Pascal Phrakonkham, and Raffaella Corvi
Part VI: The Use of Stem Cells
15. Use of Induced Pluripotent Stem Cells in Drug Toxicity Screening
Caroline Rauch, Paul Jennings, and Anja Wilmes
16. Human Stem/Progenitor Cell-Based Assays for Neurodevelopmental Toxicity Testing
Ellen Fritsche
Part VII: Techniques and Markers
17. High Content Imaging Approaches for In Vitro Toxicology
Marianne Uteng, Davide Germano, Kamal Kumar Balavenkatraman, Francois Pognan, and Armin Wolf
18. Application of Omics Technologies to In Vitro Toxicology
Nina V. Balmer, Tyna Dao, Marcel Leist, Kinga Vojnits, Tanja Waldmann, Liang Zhao, Helena T. Hogberg, and Erwin van Vliet
19. Stress Response Pathways
Martin O. Leonard, Alice Limonciel, and Paul Jennings
20. Translational Biomarkers, In Vitro and In Vivo
Anja Wilmes, Alice Limonciel, Martin O. Leonard, and Paul Jennings
Part VIII: Challenges and Considerations
21. Nanotoxicology
Agnieszka Kinsner-Ovaskainen, Pascal Colpo, Jessica Ponti and François Rossi
22. Consideration of Metabolism in In Vitro Cellular Systems
Olavi Pelkonen, Jorma T. Ahokas, Jukka Hakkola, and Miia Turpeinen
23. In Vitro Approaches to Predictive Biokinetics
Bas J. Blaauboer
24. Extrapolating In Vitro Results to Predict Human Toxicity
Nadia Quignot, Jérémy Hamon, and Frederic Y. Bois
25. Considerations in the Development of In Vitro Toxicity Testing Methods Intended for Regulatory Use
Sandra Coecke, Gerard Bowe, Anne Milcamps, Camilla Bernasconi, Ann-Charlotte Bostroem, Gilles Bories, Salvador Fortaner, Jean-Michel Gineste, Varvara Gouliarmou, Ingrid Langezaal, Roman Liska, Emilio Mendoza, Siegfried Morath, Vittorio Reina, Iwona Wilk-Zasadna and Maurice Whelan.
