Inhibition of colon cancer by Indomethacin and Juglone
Home > General > Inhibition of colon cancer by Indomethacin and Juglone
Inhibition of colon cancer by Indomethacin and Juglone

Inhibition of colon cancer by Indomethacin and Juglone


     0     
5
4
3
2
1



Out of Stock


Notify me when this book is in stock
About the Book

Inhibition of colon cancer by Indomethacin and Juglone is a promising approach for the prevention and treatment of colon cancer. The study conducted by A. Seetha highlights the potential of these two compounds in suppressing the development and progression of colon cancer. Colon cancer is a major health problem worldwide, and chemoprevention is a promising approach to reduce the incidence and mortality of this disease. Indomethacin, a nonsteroidal anti-inflammatory drug (NSAID), and Juglone, a natural compound found in walnuts and other plants, have been shown to have chemopreventive effects against colon cancer. Both compounds are known to induce apoptosis, cell cycle arrest, and inhibit tumor growth, angiogenesis, and metastasis in colon cancer cells. The mechanisms of action of Indomethacin and Juglone involve the modulation of several signaling pathways involved in cancer development and progression. Indomethacin inhibits the activity of cyclooxygenase-2 (COX-2), an enzyme that plays a critical role in the production of prostaglandin E2 (PGE2), a key mediator of inflammation and tumor growth. Inhibition of COX-2 and PGE2 has been shown to suppress the activity of nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), and phosphoinositide 3-kinase (PI3K)/Akt signaling pathways, which are important for the survival and proliferation of cancer cells. Juglone has been shown to inhibit the Wnt/β-catenin, Notch, and Hedgehog signaling pathways, which are critical for the development and maintenance of colon cancer stem cells. Indomethacin and Juglone also modulate the expression of several key genes and proteins involved in the regulation of apoptosis, cell cycle progression, oxidative stress, and inflammation. Indomethacin induces the expression of caspases and Bax, and inhibits the expression of Bcl-2, leading to the induction of apoptosis in cancer cells. Juglone induces the expression of Nrf2, a transcription factor that regulates the expression of antioxidant and detoxification genes, leading to the reduction of oxidative stress in cancer cells. Preclinical and clinical studies have shown promising results for the use of Indomethacin and Juglone in the prevention and treatment of colon cancer. In preclinical studies, both compounds have been shown to inhibit the growth of colon cancer cells in vitro and in vivo, and to suppress the development of colon tumors in animal models. Clinical trials have also shown promising results for the use of Indomethacin and Juglone in the prevention and treatment of colon cancer, with minimal side effects. In conclusion, the study conducted by A. Seetha highlights the potential of Indomethacin and Juglone as chemopreventive agents for colon cancer. The mechanisms of action of these compounds involve the modulation of several signaling pathways involved in cancer development and progression, as well as the regulation of key genes and proteins involved in apoptosis, cell cycle progression, oxidative stress, and inflammation. Further studies are needed to fully understand the potential of these compounds and to develop effective strategies for their use in the prevention and treatment of colon cancer.



Best Sellers



Product Details
  • ISBN-13: 9781805305385
  • Publisher: Independent Author
  • Binding: Paperback
  • Language: English
  • Returnable: Y
  • Weight: 231 gr
  • ISBN-10: 1805305387
  • Publisher Date: 07 Jul 2023
  • Height: 229 mm
  • No of Pages: 114
  • Spine Width: 7 mm
  • Width: 152 mm


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Inhibition of colon cancer by Indomethacin and Juglone
Independent Author -
Inhibition of colon cancer by Indomethacin and Juglone
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Inhibition of colon cancer by Indomethacin and Juglone

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    New Arrivals



    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!