Insilico Analysis of Docking Between HIV-1 PR and Derivatives of Cui
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Insilico Analysis of Docking Between HIV-1 PR and Derivatives of Cui

Insilico Analysis of Docking Between HIV-1 PR and Derivatives of Cui


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About the Book

HIV-1 Proteases (PR) are an enzyme which cleaves the long HIV polyprotein into small functional peptide fragment. These small fragments again terminate into mature HIV. Inhibition of cleavage of poly protein into small peptide fragment could prevent regeneration of HIV. Computational docking between HIV-1 PR and derivatives of Cyclic Urea Inhibitors (CUIs) has provide us clue to design drug against AIDS. Computational approaches were used to dock ligand (CUIs) with HIV-1 PR to stop cleavage. CUIs are seven-member ring structure of cyclic urea compound. It incorporates the hydrogen-bonding equivalents of an enzyme-bound water molecule into a low molecular weight. Our result suggest that some of derivatives of CUIs binds with HIV-1 PR, which can be stop the fuction of HIV-1 PR(cleavage of long protein chain into small peptide fragment).Evaluation of docking results was performed based on steric complementarity. This can be called the best fitting of ligand to the enzyme pocket. The following three factors are primarily involved to influence binding conformation between ligand and a protein.These are binding energy, hydrogen bonding, and hydrophobic interaction.


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Product Details
  • ISBN-13: 9783844384765
  • Publisher: Lap Lambert Academic Publishing
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Spine Width: 6 mm
  • Width: 152 mm
  • ISBN-10: 3844384766
  • Publisher Date: 06 Jun 2011
  • Height: 229 mm
  • No of Pages: 104
  • Series Title: English
  • Weight: 213 gr


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Insilico Analysis of Docking Between HIV-1 PR and Derivatives of Cui
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Insilico Analysis of Docking Between HIV-1 PR and Derivatives of Cui
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