Izuchenie Gena Gstp1 U Bol'nykh Rakom Molochnoy Zhelezy V Kbr
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Izuchenie Gena Gstp1 U Bol'nykh Rakom Molochnoy Zhelezy V Kbr

Izuchenie Gena Gstp1 U Bol'nykh Rakom Molochnoy Zhelezy V Kbr


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About the Book

Onkogenez yavlyaetsya rezul'tatom deystviya mnogikh genov tak nazyvaemoy gennoy seti, a genam biotransformatsii ksenobiotikov otvoditsya rol' modifikatorov funktsiy glavnykh genov. Sboi v sisteme detoksikatsii ksenobiotikov okazyvayut sushchestvennoe vliyanie na razvitie RMZh. Byl proveden analiz genov, kontroliruyushchikh detoksikatsiyu ksenobiotikov u bol'nykh RMZh, prozhivayushchikh na territorii KBR. Vyyavleny chastoty vstrechaemosti polimorfizma Ile105Val gena GSTP1 u bol'nykh RMZh i v kontrol'noy gruppe. Sravnitel'nyy analiz chastot alleley issleduemogo polimorfnogo varianta mezhdu bol'nymi rakom molochnoy zhelezy i gruppoy kontrolya pokazal, chto chastota allelya Ile dostigaet 92.5% u bol'nykh RMZh i 98 % u zdorovykh lits. Chastota alleli Val v issledovannoy gruppe bol'nykh ravna 0,075, togda kak v kontrol'noy gruppe sostavila 0,012. Genotip IleIle vyyavlen s chastotoy 97.5% (39/40 chel) i 85% (34/40 chel.) u zdorovykh lits i bol'nykh RMZh, sootvetstvenno. Geterozigotnyy genotip identifitsirovan s chastotoy 2.5% (1/40 chel) u kontrol'noy gruppy i 15% (6/40 chel.) u bol'nykh RMZh. Gomozigoty po allelyu Val ne byli zaregistrirovany ni v odnoy iz vyborok.


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Product Details
  • ISBN-13: 9783659236013
  • Publisher: Lap Lambert Academic Publishing
  • Binding: Paperback
  • Language: Russian
  • Returnable: N
  • Spine Width: 3 mm
  • Width: 152 mm
  • ISBN-10: 3659236012
  • Publisher Date: 07 Sep 2012
  • Height: 229 mm
  • No of Pages: 52
  • Series Title: Russian
  • Weight: 141 gr


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Izuchenie Gena Gstp1 U Bol'nykh Rakom Molochnoy Zhelezy V Kbr
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