Martin Chuzzlewit has been raised by his grandfather and namesake. Years before Martin senior took the precaution of raising an orphaned girl, Mary Graham, to be his nursemaid, with the understanding that she will be well cared for only as long as Martin senior lives. She thus has a strong motive to promote his well-being, in contrast to his relatives, who want to inherit his money. However, his grandson Martin falls in love with Mary and wishes to marry her, ruining Martin senior's plans. When Martin refuses to give up the engagement his grandfather disinherits him.
Martin becomes an apprentice to Seth Pecksniff, a greedy architect. Instead of teaching his students he lives off their tuition fees and has them do draughting work that he passes off as his own. He has two spoiled daughters, Charity and Mercy, nicknamed Cherry and Merry. Unbeknown to Martin, Pecksniff has taken him on in order to establish closer ties with his wealthy grandfather.
Young Martin befriends Tom Pinch, a kind-hearted soul whose late grandmother gave Pecksniff all she had in the belief that Pecksniff would make an architect and a gentleman of him. Pinch is incapable of believing any of the bad things others tell him of Pecksniff, and always defends him vociferously. Pinch works for exploitatively low wages while believing that he is the unworthy recipient of Pecksniff's charity.
On Christmas Eve, around 1812, Pip, an orphan who is about seven years old, encounters an escaped convict in the village churchyard, while visiting the graves of his parents and siblings. Pip now lives with his abusive elder sister and her kind husband Joe Gargery, a blacksmith. The convict scares Pip into stealing food and a file. Early on Christmas morning Pip returns with the file, a pie and brandy. During Christmas Dinner that evening, at the moment Pip's theft is about to be discovered, soldiers arrive and ask Joe to repair some shackles. Joe and Pip accompany them as they recapture the convict who is fighting with another escaped convict. The first convict confesses to stealing food from the smithy.
A year or two later, Miss Havisham, a wealthy spinster who still wears her old wedding dress and lives as a recluse in the dilapidated Satis House, asks Mr Pumblechook, a relation of the Gargery's, to find a boy to visit her. Pip visits Miss Havisham and falls in love with her adopted daughter Estella. Estella remains aloof and hostile to Pip, which Miss Havisham encourages. Pip visits Miss Havisham regularly, until he is old enough to learn a trade.
Joe accompanies Pip for the last visit, when she gives the money for Pip to be bound as apprentice blacksmith. Joe's surly assistant, Dolge Orlick, is envious of Pip and dislikes Mrs Joe. When Pip and Joe are away from the house, Mrs Joe is brutally attacked, leaving her unable to speak or do her work. Orlick is suspected of the attack. Mrs Joe becomes kind-hearted after the attack. Pip's former schoolmate Biddy joins the household to help with her care.