Lipid a in Cancer Therapy by Jean-Francois Jeannin
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Lipid a in Cancer Therapy

Lipid a in Cancer Therapy


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About the Book

Introduction: Historical Background.- Structure andSynthesis of Lipid A.- Conformation and Supramolecular Structure of Lipid A.- Interactions between Lipid A and Serum Proteins.- The Lipid A Receptor.- Lipid A Receptor TLR4-Mediated Signaling Pathways.- Lipid A-Induced Responses In Vivo.- Lipid A-Mediated Tolerance and Cancer Therapy.- Lipid A in Cancer Therapies Preclinical Results.- Monophosphoryl Lipid A (MPL) as an Adjuvant for Anti-Cancer Vaccines: Clinical Results.- Antitumoral Effects of Lipids A, Clinical Studies.- Conclusion.
About the Author:

Jean-François Jeannin is Professor of Immunology at Ecole Practique des Hautes Etudes (EPHE) and director of the EPHE Tumor Immunology and Immunotherapy Laboratory, an INSERM (National Institute of Health and Medical Research) team. His main research interests have included the effects of lipopolysaccharides in the tumor immune response and the immunotherapy of colon cancer with lipid A. Now he is investigating mechanisms of immunotherapy with synthetic lipid A analogs in cancer patients and animal cancer models. He is especially interested in the sensitization of tumor cell death by nitric oxide produced in tumors during lipid A immunotherapy.

Jean-François Jeannin has been Dean and President of the Life Sciences faculty of EPHE and a member of numerous scientific organizations.


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Product Details
  • ISBN-13: 9781461424970
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Edition: 2010 ed.
  • Language: English
  • Returnable: Y
  • Spine Width: 8 mm
  • Width: 156 mm
  • ISBN-10: 1461424976
  • Publisher Date: 25 Feb 2012
  • Binding: Paperback
  • Height: 234 mm
  • No of Pages: 152
  • Series Title: Advances in Experimental Medicine and Biology
  • Weight: 277 gr


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