Part I. Historical and Methodology Overview
1. Overview: of Mass Spectrometry Based Metabolomics: Opportunities and Challenges
G. A. Nagana Gowda and Danijel Djukovic
Part II. Global LC-MS Based Metabolic Profiling
2. Global Metabolic Profiling using Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry
Yunpeng Qi, Yunlong Song, Haiwei Gu, Guorong Fan, and Yifeng Chai
3. LC-MS Profiling to Link Metabolic and Phenotypic Diversity in Plant Mapping Populations
Camilla B. Hill, Antony Bacic, and Ute Roessner
4. Mitochondrial Metabolomics Using High-Resolution Fourier-Transform Mass Spectrometry
Young-Mi Go, Karan Uppal, Douglas I. Walker, ViLinh Tran, Lauriane Dury, Frederick H. Strobel, Hélène Baubichon-Cortay, Kurt D. Pennell, James R. Roede, and Dean P. Jones
5. Sample Preparation Methods for LC-MS Based Global Aqueous Metabolite Profiling
Antoni Beltran, Sara Samino, and Oscar Yanes
Part III. Global GC-MS and CE-MS Based Metabolic Profiling
6. Methods of Discovery-Based and Targeted Metabolite Analysis by Comprehensive Two-Dimensional Gas Chromatography with Time-of-Flight Mass Spectrometry Detection
Luke C. Marney, Dr. Jamin C. Hoggard, Kristen J. Skogerboe, and Robert E. Synovec
7. Analysis of Mouse Liver Metabolites by GC×GC-TOF MS
Xue Shi, Xinmin Yin, and Xiang Zhang
8. Metabolite Fingerprinting by Capillary Electrophoresis-Mass Spectrometry
Antonia Garcia, Shama Naz, and Coral Barbas
Part IV. Isotope Labeling Methods
9. Quantitative Metabolomic Profiling using Dansylation Isotope Labeling and Liquid Chromatography Mass Spectrometry
Ruokun Zhou and Liang Li
10. Quantitative Analysis of Amino and Organic Acids by Methyl Chloroformate Derivatization and GC-MS/MS Analysis
Hans Fredrik Nyvold Kvitvang, Kåre A. Kristiansen, Stina K. Lien, and Per Bruheim
11. Stable Isotope Labeled Tracers for Metabolic Pathway Elucidation by GC-MS and FT-MS
Richard M. Higashi, Teresa W-M. Fan, Pawel K. Lorkiewicz, Hunter N.B. Moseley, and Andrew N. Lane
Part V. Targeted Aqueous Metabolite Profiling
12. Multiplexed, Quantitative and Targeted Metabolite Profiling by LC-MS/MRM
Ru Wei, Guodong Li, and Albert B. Seymour
Part VI. Lipid Profiling Methods
13. Multi-Dimensional Mass Spectrometry-Based Shotgun Lipidomics
Miao Wang and Xianlin Han
14. Comprehensive Quantitative Determination of PUFA-Related Bioactive Lipids for Functional Lipidomics using High Resolution Mass Spectrometry
Mojgan Masoodi and Dietrich A. Volmer
15. Ultra-Performance Liquid Chromatography Mass Spectrometry Targeted Profiling of Bile Acids: Application to Serum, Liver Tissue and Cultured Cells of Different Species
Juan Carlos García-Cañaveras, María Teresa Donato, and Agustín Lahoz
Part VII. Profiling Volatile Organic Compounds
16. Analysis of Volatile Organic Compounds in Exhaled Breath by Gas Chromatography-Mass Spectrometry combined with Chemometric Analysis
Jan W. Dallinga, Agnieszka Smolinska, and Frederik-Jan van Schooten
17. Headspace SPME-GC-MS Metabolomics Analysis of Urinary Volatile Organic Compounds (VOCs)
Shucha Zhang and Daniel Raftery
Part VIII. Profiling and Imaging using Atmospheric Sampling Methods