Mathematical Modeling and Scale-Up of Liquid Chromatography
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Mathematical Modeling and Scale-Up of Liquid Chromatography

Mathematical Modeling and Scale-Up of Liquid Chromatography


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About the Book

Introduction.- Literature Review.- General Multicomponent Rate Models for Column Liquid Chromatography.- Numerical Solutions and Computer Software with Graphical User Interface.- Mass Transfer Effects.- Interference Effects in Multicomponent Chromatography.- System Peaks In Multicomponent Elution.- Multicomponent Adsorption with Uneven Saturation Capacities.- Modeling of Size Exclusion Chromatography.- Modeling of Ion-Exchange Chromatography with Steric Mass-Action Isotherm.- Modeling of Chromatography with Cored Beads - Advantages And Limitations.- Modeling of Affinity Chromatography.- Modeling of Multicomponent Gradient Elution.- Multicomponent Radial Flow Chromatography.- Parameter Estimation and Parameter Sensitivity Analysis.- Scale-Up Methods and Examples.
About the Author:

Dr. Tingyue Gu is a professor in the Department of Chemical & Biomolecular Engineering at Ohio University. He obtained his PhD degree in chemical engineering from Purdue University in 1990. His PhD work was devoted to liquid chromatography (LC) theories and modeling. Dr. Gu has solved a series of LC models numerically for various forms of LC and developed a comprehensive software package with graphical user interface. His software has been used in over 34 countries by numerous people. The software is offered for free for academic applications. It has also been commercially licensed by major companies including leading biotech and pharmaceutical companies. The software has been successfully used for product development with huge savings in time through simulation. Apart from LC, his current research also encompasses bioenergy, biofilm electrochemistry, biocorrosion, and microbial fuel cells.


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Product Details
  • ISBN-13: 9783319161440
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Depth: 19
  • Height: 234 mm
  • No of Pages: 207
  • Series Title: English
  • Sub Title: With Application Examples
  • Width: 156 mm
  • ISBN-10: 331916144X
  • Publisher Date: 14 Apr 2015
  • Binding: Hardback
  • Edition: 2
  • Language: English
  • Returnable: N
  • Spine Width: 14 mm
  • Weight: 539 gr


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Mathematical Modeling and Scale-Up of Liquid Chromatography
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