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Metastasis of Colorectal Cancer

Metastasis of Colorectal Cancer


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Introduction; N. Beauchemin, J. Huot 1. The Metastatic Process: an Overview; N.Porquet, S. Guot, J. Huot 1.1 Models of metastasis - 1.1.1 The progression model - 1.1.2 The transient compartment model - 1.1.3 The early oncogenesis model - 1.1.4 The fusion model - 1.1.5 The gene transfer models - 1.1.6 The genetic predisposition model 1.2 Metastatic steps - 1.2.1 Development of the primary colorectal cancer - 1.2.1.1 Initiation of the primary neoplasm - 1.2.1.2 Influence of stromal cells - 1.2.1.3 Influence of the extracellular matrix - 1.2.1.4 Epithelial-Mesenchymal transition - 1.2.1.5 Angiogenesis and lymphangiogenesis - 1.2.2 Intravasation - 1.2.3 Circulation of cancer cells - 1.2.4 Extravasation - 1.2.4.1 The adhesion on endothelial cells and the homing concept of metastasis - 1.2.4.2 The passage across the endothelium 1.2.5 Colonization of the secondary sites 1.3 Concluding Remarks References 2. Physiopathology of Colorectal Metastasis; C. Ferrario, M. Basik 2.1 Mechanisms of metastatic spread - 2.1.1 Circulatory spread - 2.1.1.1 Lymphatic spread - 2.1.1.2 Hematogenous spread - 2.1.2 Local spread - 2.1.3 Tumour dormancy 2.2 Sites of metastasis and consequences of spread - 2.2.1 Liver - 2.2.1.1 Steps in liver invasion - 2.2.1.2 Development of liver failure - 2.2.2 Lungs - 2.2.3 Peritoneum - 2.2.4 Bone and bone marrow - 2.2.5 Brain metastasis 2.3 factors contributing to metastatic spread - 2.3.1 Tumour factors - 2.3.1.1 Tissue Factor - 2.3.1.2 EGFR - 2.3.2 Host factors - 2.3.2.1 Immunity - 2.3.2.2 Diet, exercise and liver disease - 2.3.3 Iatrogenic factors 2.4 Conclusion References 3. The Genetic of Colorectal Cancer; A.M. Kaz, W.M. Grady 3.1 Introduction 3.2 The Adenoma-to-Carcinoma Sequence 3.3 Genomic Instability - 3.3.1 Overview - 3.3.2 Chromosome Instability - 3.3.3 DNA Mismatch Repair Inactivation and Microsatellite Instability - 3.3.4 Base Excision Repair Defects/MYH 3.4 Common Deregulated Signalling Pathways - 3.4.1 Wingless/Wnt Signalling Pathway - 3.4.1.1 APC - 3.4.1.2 B-Catenin (CTNNB1) - 3.4.2 KRAS, BRAF and RAS-RAF-MAPK Signalling Pathway - 3.4.2.1 K-RAS - 3.4.2.2 BRAF - 3.4.3 p53 (TP53) - 3.4.4 The Phosphatidylinositol 3-kinase (PI3K) Pathway - 3.4.4.1 PIK3CA - 3.4.4.2 PTEN - 3.4.5 TGF-B Signalling Pathways - 3.4.5.1 TGFBR2 - 3.4.5.2 The SMAD Family of Genes - 3.4.5.3 TGF-B Superfamily Receptors: ACVR2 and BMPR1A 3.5 Genome-Wide Analyses of Colorectal Cancer Genes 3.6 Metastasis Genes 3.7 Conclusions References 4. Epigenetics of Colorectal Cancer; F.J. Carmona, M. Esteller 4.1 Introduction 4.2 DNA methylation defects in colorectal cancer - 4.2.1 Hypomethylation of DNA 4.3 Inactivation of tumour suppressor genes by CpG island hypermethylation 4.4 Epigenetic regulation of microRNA in cancer 4.5 MicroRNAs as metastasis switches 4.6 Histone modification defects in colon cancer 4.7 Epigenetic contribution to co


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Product Details
  • ISBN-13: 9789400732933
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Height: 234 mm
  • No of Pages: 416
  • Series Title: Cancer Metastasis - Biology and Treatment
  • Weight: 657 gr
  • ISBN-10: 9400732937
  • Publisher Date: 13 Oct 2012
  • Binding: Paperback
  • Language: English
  • Returnable: Y
  • Spine Width: 22 mm
  • Width: 156 mm


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