Microambiente tumoral de pacientes com câncer de ovário by Rodrigo Fernandes Da Silva
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Microambiente tumoral de pacientes com câncer de ovário

Microambiente tumoral de pacientes com câncer de ovário


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About the Book

Ascite peritoneal é uma característica distinguível de pacientes com câncer de ovário avançado e é formada por uma resposta inflamatória ao tumor maligno. A presença de diferentes subtipos de linfócitos tem sido relatada por exercer funções ativadoras ou inibidoras na resposta imune contra o tumor neste microambiente tumoral. Caracterizamos o líquido ascítico de pacientes com câncer de ovário em relação aos subtipos de linfócitos, citocinas e atividade funcional das células natural killer (NK). Descrevemos as características fenotípicas e moleculares de uma linhagem tumoral de ovário CAISMOV24, estabelecida a partir de uma amostra de ascite carcinomatosa obtida durante o estudo, e comparar as alterações genômicas entre a linhagem e suas células primárias. O desempenho funcional das células NK foi distinta entre ascites carcinomatosas e não carcinomatosas. As ascites carcinomatosas apresentaram um microambiente tumoral imunossupressor, com altos níveis de linfócitos T-reg, supressão dos receptores ativadores da células NK e reposta ineficiente das células NK ao estímulo com IL-2, medida através da degranulação.


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Product Details
  • ISBN-13: 9786139727964
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Novas Edicoes Academicas
  • Height: 229 mm
  • No of Pages: 104
  • Spine Width: 6 mm
  • Width: 152 mm
  • ISBN-10: 6139727960
  • Publisher Date: 10 Jan 2019
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Weight: 213 gr


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