Monitoring der Antikoagulanzientherapie mittels Bestimmung von Prothrombinzeit/INR und chromogenem Faktor X bei Patienten mit Antiphospholipid-Syndrom
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Monitoring der Antikoagulanzientherapie mittels Bestimmung von Prothrombinzeit/INR und chromogenem Faktor X bei Patienten mit Antiphospholipid-Syndrom

Monitoring der Antikoagulanzientherapie mittels Bestimmung von Prothrombinzeit/INR und chromogenem Faktor X bei Patienten mit Antiphospholipid-Syndrom


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About the Book

Antiphospholipidantikorper (APL) konnen die INR-Wert-Bestimmung durch Interaktion von Lupusantikoagulanzien mit den Phospholipiden im Testansatz storen. Dies fuhrt moglicherweise zu falsch zu hohen INR-Werten bei antikoagulierten Patienten mit Antiphospholipid-Syndrom (APS), die zur Sekundarpravention nach einem thrombotischem Ereignis unter Therapie mit Vitamin-K-Antagonisten (VKA) stehen. Vergleichsmessungen bei APS-Patienten und APL-negativen Kontrollen zeigten Abweichungen zwischen INR-Wert und der phosphilipid-unabhangigen chromogenen Messung der Faktor-X-Aktivitat (CFX) in beiden Gruppen. Zum INR-Monitoring bei APS weisen die gewebe-extrahierten Thromboplastine Thromborel S und Neoplastin Plus eine hohere Messgenauigkeit auf als die rekombinanten Thromboplastine, zu denen auch das CoaguChek XS-System gehort. Fur die meisten APS-Patienten ist ein INR-Monitoring zur Uberwachung einer VKA-Therapie moglich. Allerdings sollte bei erneuten thromboembolischen Ereignissen trotz therapeutischem INR an die Moglichkeit einer Interferenz von Lupusantikoagulanzien gedacht werden und ein phospholipid-unabhangiges Verfahren wie die CFX-Bestimmung zum Einsatz kommen.


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Product Details
  • ISBN-13: 9783736993372
  • Publisher: Na
  • Height: 210 mm
  • Weight: 5 gr
  • ISBN-10: 3736993374
  • Binding: Paperback
  • Language: English;German
  • Width: 131 mm


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Monitoring der Antikoagulanzientherapie mittels Bestimmung von Prothrombinzeit/INR und chromogenem Faktor X bei Patienten mit Antiphospholipid-Syndrom
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