In this book, experts in the field provide comprehensive descriptions of the neuroanatomy of the hypothalamic neuroendocrine systems.
The book begins with an extensive discussion on the structural components of the neuroendocrine systems. The reader will be introduced to the anatomy and biology of the hypothalamus and the pituitary. The human hypothalamus is presented in particular detail using state-of-the-art imaging techniques. In the next section, the neuroanatomy of traditional hypothalamo-hypophyseal systems is highlighted, with chapters describing magnocellular neuroendocrine cells and discussing the respective types of hypothalamic neurons that regulate various pituitary hormones. Following this detailed structural and anatomical description of the neuroendocrine system, the book's final section focuses on the hypothalamic control of neuroendocrine functions. This includes the control of circadian rhythm, metabolism and appetite via specific peptidergic circuits.
This book provides essential information on the neuroanatomy and control of neuroendocrine systems, addresses cutting-edge research questions posed by recent advances in the development of potent neuroanatomical tools, and highlights the latest technologies used in neuroendocrinology research, making it a valuable reference guide for students, trainees and established researchers alike.
This is the twelfth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series, which aims to illustrate the highest standards and to encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.
About the Author: Valery Grinevich received his MD in 1992 (Kursk State Medical University, Russia) and PhD in 1996 (Russian Academy of Sciences, Saint-Petersburg). As a postdoctoral fellow, he worked with leading experts in neuroendocrinology, Georges Pelletier and Ferdinand Labrie (Quebec), and Greti Aguilera (NIH) focusing on neuroendocrine mechanisms of the stress response. In 2003, he joined the team of Peter H. Seeburg at the Max Planck Institute for Medical Research (MPIMF) Heidelberg. In 2008, he established his own group at the MPIMF and in 2012 - the Independent Schaller Group on Neuropeptides in Heidelberg. During the last decade, Grinevich's team deciphered a novel mechanism of neuropeptide signalling in the brain: axonal oxytocin release modulating brain region specific behaviors. His work was supported by the Chica and Heinz Schaller Foundation, a number of German and European Agencies, and by the Human Frontier Science Program. In 2019 he has been promoted as Full University Professor and Chair of Department of Neuropeptide Research in Psychiatry at the Central Institute of Mental Health of the Heidelberg University as well as Affiliate Professor at the Georgia State University, Atlanta, USA. In 2021, Valery Grinevich received an award for his exceptional research contributions to the study of neuropeptides from the European College of Neuropsychopharmacology (ECNP).
Árpád Dobolyi received his PhD degree at Semmelweis Medical University (Budapest, Hungary) in 2000. It was followed by a postdoctoral period at NIMH in the laboratory of Ted Usdin in Bethesda, USA. Then, he received a Marie Curie Fellowship from the European Commission to work in the laboratory of Prof. Miklós Palkovits in Hungary. Árpád Dobolyi founded his own research group in 2013 in the Department of Anatomy, Histology and Embryology at Semmelweis University, and focused on endocrine and behavioral changes in the maternal brain using biological systems approaches. Four years later, he was promoted to Full University Professor at Eotvos Lorand University, Budapest where he uses chemogenetic and RNA sequencing methods to understand subcortical mechanisms of social interactions in the Laboratory of Molecular and Systems Neurobiology also supported by the Hungarian Academy of Sciences. He is the Head of the Department of Physiology and Neurobiology at Eotvos Lorand University, Budapest since 2018.
