nobiletine atténue l'hépatotoxicité oxydative induite par le chrome chez le rat
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nobiletine atténue l'hépatotoxicité oxydative induite par le chrome chez le rat

nobiletine atténue l'hépatotoxicité oxydative induite par le chrome chez le rat


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About the Book

Le potentiel préventif de la nobiletine, une flavone d'agrume polyméthoxylée, sur la réduction de l'hépatotoxicité médiée par le stress oxydatif induit par le chrome chez les rats mâles adultes a été étudié. Le chrome (Cr) est un métal lourd toxique qui provoque probablement un stress oxydatif en altérant le système antioxydant hépatique. La présente étude se concentre sur (i) l'étude de l'effet toxique du chrome dans le foie des rats, ainsi que (ii) l'effet protecteur de la nobiletine sur les rats intoxiqués par le chrome. Du chrome (700 ppm) a été administré par voie orale pendant 21 jours, à 24 heures d'intervalle. La nobiletine (75 mg) a été administrée au préalable aux rats témoins et aux rats traités au cadmium. Les animaux ont été sacrifiés le 22e jour après le dernier traitement. Le sang et les tissus hépatiques ont été prélevés et immédiatement immergés dans une solution PBS pour l'évaluation des variables biochimiques, et un petit lobe du foie a été fixé dans du formol à 10 % pour l'évaluation au microscope optique. Suite à l'intoxication au chrome, une diminution significative a été observée dans le système antioxydant du foie ainsi qu'une augmentation des marqueurs de stress oxydatif, qui a été normalisée par le prétraitement à la nobiletine.


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Product Details
  • ISBN-13: 9786206444749
  • Publisher: KS Omniscriptum Publishing
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Weight: 231 gr
  • ISBN-10: 6206444740
  • Publisher Date: 12 Sep 2023
  • Height: 229 mm
  • No of Pages: 116
  • Spine Width: 7 mm
  • Width: 152 mm


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nobiletine atténue l'hépatotoxicité oxydative induite par le chrome chez le rat
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nobiletine atténue l'hépatotoxicité oxydative induite par le chrome chez le rat
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