Nouvelles α-Glucosidases en tant qu'inhibiteurs antidiabétiques
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Nouvelles α-Glucosidases en tant qu'inhibiteurs antidiabétiques

Nouvelles α-Glucosidases en tant qu'inhibiteurs antidiabétiques


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About the Book

Dans cet ouvrage, différentes méthodes de conception de médicaments assistée par ordinateur (CADD) ont été utilisées pour concevoir de nouveaux inhibiteurs qui peuvent être utilisés pour traiter les maladies du diabète. Des relations quantitatives tridimensionnelles structure-activité (3D-QSAR) et des approches de docking moléculaire ont été appliquées pour découvrir et rationaliser de nouvelles molécules hétérocycliques bioactives contenant de l'azote en tant que nouveaux inhibiteurs de l'α-glucosidase. En outre, la règle des cinq de Lipinski et la pharmacocinétique ADME/Tox ont également été utilisées pour évaluer la biodisponibilité orale et étudier la toxicité des molécules nouvellement conçues. Toutes les méthodes in silico montrent des résultats prometteurs en tant que médicaments candidats antidiabétiques. En outre, il n'existe aucune similitude chimique entre les composés conçus et les médicaments utilisés et étudiés dans la littérature ou les bases de données. Par conséquent, les résultats obtenus dans ce livre encouragent à poursuivre les études expérimentales et scientifiques sur les composés nouvellement conçus, qui pourraient être des agents antidiabétiques dotés d'une forte puissance inhibitrice. Dans ce livre, nous nous concentrerons sur les nombreux articles scientifiques intéressants publiés par notre groupe de recherche dans un certain nombre de revues nationales et internationales réputées.


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Product Details
  • ISBN-13: 9786206907206
  • Publisher: KS Omniscriptum Publishing
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Sub Title: Approches in silico
  • Width: 152 mm
  • ISBN-10: 6206907201
  • Publisher Date: 03 Dec 2023
  • Height: 229 mm
  • No of Pages: 96
  • Spine Width: 6 mm
  • Weight: 199 gr


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