Oral Anticoagulation Therapy: Cases and Clinical Correlation

Given the amount and complexity of information surrounding the the target specific oral anticoagulants a lengthy didactic educational format has the potential to be overwhelming to the reader and difficult to translate and apply to direct patient care. The proposed book will educate clinicians utilizing a series of clinical cases to simultaneously develop the readers’ knowledge base, problem-solving skills, and practically apply their new knowledge to a variety of clinical situations. These will be short focused case presentations that provide critical information and pose questions to the reader at key points in the decision making process. The cases will be relevant to what clinicians will encounter not only on a daily basis, but also reflective of scenarios that clinicians will not encounter regularly, but that they will have to act upon (e.g. a bleeding patient, patient scheduled for elective or emergent procedure, patient with changing renal function, patient on drugs that have aplausible yet unstudied drug interaction with a target specific oral anticoagulant etc).  Included in the case studies will be evidence-based discussions (with appropriate references) that provide immediate feedback on the different treatment alternatives that were offered.  The case studies will be designed to instruct the reader how to select and effectively utilize the most appropriate agent for a given clinical scenario. They will focus on key features of the target specific oral anticoagulants, what they have in common, how they are unique from each other, as well as illustrating the clinical decision process one should take when selecting an agent or managing a patient already receiving one of the target specific oral agents. ? 

Table of Contents:
Atrial Fibrillation: Basic simple introductory case.- Patient who desires best reduction in ischemic stroke possible.- Elderly patient (e.g. > 80 years old) .- Patient with prior history of GI hemorrhage.- Patient with history of intracranial hemorrhage while on warfarin.- Patient with history of adherence issues who uses pill box.- Patient with stable moderate chronic kidney disease.- Patient with variable renal function.- Patient with concomitant coronary artery disease.- Patient with concomitant history of venous thromboembolism.- Venous Thromboembolism (VTE): Patient with new DVT.- Patient with new PE.- Patient s/p hip replacement.- Patient in ICU in need of DVT prophylaxis.- Patient with VTE and concomitant atherosclerotic disease.- Patient with DVT in ICU with feeding tube.- Patient with moderate chronic kidney disease and VTE.- Patient with recurrent VTE.- Patient with PE who underwent thrombolytic therapy.- Patient s/p knee replacement.- Acute Coronary Syndrome: Patient on a new oral anticoagulant presenting with ACS.- Patient post PCI.- Patient with ACS with additional indication for oral anticoagulant.- Patient with ST segment elevation MI (lytic candidate) on new oral anticoagulant.- Patient with ACS who will be undergoing bypass surgery.- Drug Interactions: CYP 3A4 inhibitors.- PgP inhibitors.- Pharmacodynamic interactions.- Mixed CYP 3A4/PgP inhibitors.- Plausible (but unproven) drug interactions (e.g. cyclosporine) .- Special Populations: Atrial fibrillation ablation.- Mechanical valves.- Coagulopathies.- Pregnancy.- Malignancies.- Perioperative management-minor procedures.- Perioperative management-major procedures.​