Osteoporose, das Immunsystem und die Genetik
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Osteoporose, das Immunsystem und die Genetik

Osteoporose, das Immunsystem und die Genetik


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About the Book

Osteoporose ist eine degenerative, multifaktorielle Osteometabolismus-Erkrankung, die durch eine Abnahme der Knochenmineraldichte und eine Verschlechterung der Mikroarchitektur des Gewebes gekennzeichnet ist. Von den verschiedenen systemischen und lokalen Faktoren, die an der Ätiopathogenese der Krankheit beteiligt sind, hat sich die Verbindung zwischen Komponenten des Immunsystems und dem genetischen Hintergrund als entscheidend für die Aufrechterhaltung der Homöostase des Knochengewebes erwiesen. Da es sich um eine multifaktorielle Erkrankung handelt, ist es von entscheidender Bedeutung, dass ihre Hauptursachen frühzeitig erkannt werden, um ein Fortschreiten der Krankheit zu verhindern. Es ist bekannt, dass Zytokine an dieser Homöostase beteiligt sind, indem sie die Geweberesorption beeinflussen und die Proliferation von Knochenzellen steuern. Polymorphismen in den Genen dieser Zytokine, wie z. B. SNPs, können ihre Strukturen und Expressionsniveaus beeinträchtigen und die biologischen Mechanismen, an denen sie beteiligt sind, verändern. Ziel dieses Buches war es daher, die Rolle von IFN-γ in diesem Prozess zu überprüfen, indem der rs2069705-Polymorphismus, die Expressionswerte und die In-vitro-Aktivität des Proteins analysiert wurden. Wir hoffen, auf diese Weise dazu beizutragen, die noch bestehenden Lücken im Bereich der Osteoimmunologie bei der Untersuchung der Osteoporose zu schließen.


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Product Details
  • ISBN-13: 9786207341719
  • Publisher: KS Omniscriptum Publishing
  • Binding: Paperback
  • Language: German
  • Returnable: N
  • Weight: 145 gr
  • ISBN-10: 6207341716
  • Publisher Date: 31 Mar 2024
  • Height: 229 mm
  • No of Pages: 56
  • Spine Width: 3 mm
  • Width: 152 mm


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