Pathogenomics
Home > Mathematics and Science Textbooks > Biology, life sciences > Microbiology (non-medical) > Pathogenomics: Genome Analysis of Pathogenic Microbes
Pathogenomics: Genome Analysis of Pathogenic Microbes

Pathogenomics: Genome Analysis of Pathogenic Microbes

|
     0     
5
4
3
2
1




Out of Stock


Notify me when this book is in stock
About the Book

The first book on this young, highly dynamic, and expanding field. This comprehensive, interdisciplinary text focuses on those pathogenic bacteria that are of high scientific and public health interest, yet which also display great potential for the development of new diagnostic, prophylactic and therapeutic procedures. The authors cover all aspects of pathogenomics, including methods, genomics and applications. In addition, the ongoing development of genome, transcriptome, proteome and bioinformatic analyses of pathogenic microorganisms and their host interactions makes for a comprehensive introduction to the field of modern genomic analysis. This result is invaluable to researchers and students wishing to gain a general overview of microbial functional genome analysis and pathogenesis, while also representing a good starting point for those new to the area.

Table of Contents:
Foreword. Preface. List of Contributors. Color Plates. I Methods. 1 Bioinformatics: Data Mining Among Genome Sequences (Susanne Kneitz and Thomas Dandekar). 1.1 Systematic Genome Analysis of Pathogens as a Basis for Pharmacogenomic Strategies. 1.2 Direct Sequence Annotation Tools for Functional Genomics. 1.3 Identification of Protein Function. 1.4 Obtaining Protein Information from a Domain Server. 1.5 Pathway Analysis. 1.6 Network Analysis. 1.7 Adaptation in Time and to Stimuli. 1.8 Pathogen-Specific Challenges. 1.9 Pathogen Adaptation Potential. 1.10 The Fight Against Resistance. 1.11 Drug Design and Antibiotics. 1.12 Annotation Platforms Suitable for Pathogenomics. 1.13 Conclusions. 2 Transcriptome Analysis: Towards a Comprehensive Understanding of Global Transcription Activity (Ben Sidders and Neil Stoker). 2.1 Introduction. 2.2 Development of Transcriptomics. 2.3 Introducing the Microarray. 2.4 Microarray Methods. 2.5 Data Normalization and Analysis. 2.6 Transcriptomics: Where We Are Now and What's to Come. 3 Physiological Proteomics of Bacillus subtilis and Staphylococcus aureus: Towards a Comprehensive Understanding of Cell Physiology and Pathogenicity (Michael Hecker and Susanne Engelmann). 3.1 Introduction. 3.2 Proteomics of Bacillus subtilis: The Gram-positive Model Organism. 3.3 Physiological Proteomics of Staphylococcus aureus. 3.4 Outlook: Second Generation Proteomics and New Fields in S. aureus Physiology and Infection Biology. 4 Impact of Genome Sequences on Mutational Analysis of Fungal and Bacterial Pathogens (Vladimir Pelicic and Xavier Nassif). 4.1 The Long Road from Sequence to Function. 4.2 Classical Genetics Still at the Forefront in the Postgenome Era. 4.3 Genome-Scale Mutational Analyses. 4.4 Conclusion. II Genomics of Pathogenic Bacteria. 5 Pathogenomics of Escherichia coli and Shigella Species (Ulrich Dobrindt and Jorg Hacker). 5.1 Introduction. 5.2 Comparative Genomics of Shigella. 5.3 Comparative Genomics of Escherichia coli. 5.4 Conclusions. 6 Pathogenomics of Salmonella Species (Helene Andrews-Polymenis and Andreas J. Baumler). 6.1 Introduction. 6.2 Salmonella Signature Genes. 6.3 Subspecies I Signature Genes. 6.4 Host Restriction. 7 Pathogenomics of Enterococcus faecalis (Janet M. Manson and Michael S. Gilmore). 7.1 Introduction. 7.2 Enterococcal Pathogenesis. 7.3 Genome Sequence of E. faecalis. 7.4 Conclusions and Future Perspectives. 8 Genomics of Streptococci (Joseph J. Ferretti and W. Michael McShan). 8.1 Introduction. 8.2 Bacterial Genomes. 8.3 Streptococcal Genomic Bacteriophages. 9 Pathogenic Staphylococci: Lessons from Comparative Genomics (Knut Ohlsen, Martin Eckart, Christian H1ttinger, and Wilma Ziebuhr). 9.1 Introduction. 9.2 Comparative Genomics of S. aureus. 9.3 Staphylococcus epidermidis. 9.4 Concluding Remarks. 10 Pathogenomics: Insights into Tuberculosis and Related Mycobacterial Diseases (Alexander S. Pym, Stephen V. Gordon, and Roland Brosch). 10.1 Introduction. 10.2 Molecular Basis of Pathogenicity. 10.3 Evolution of the M. tuberculosis Complex. 10.4 Some Metabolic Insight from the Genome Sequences. 10.5 Other Major Mycobacterial Human Pathogens. 10.6 Concluding Remarks. 11 Genomes of Pathogenic Neisseria Species (Christoph Schoen, Heike Claus, Ulrich Vogel, and Matthias Frosch). 11.1 Introduction. 11.2 Genomes of Pathogenic Neisseria Species. 11.3 Future Perspectives. 12 Genomics of Pathogenic Clostridia and Bacilli (Armin Ehrenreich, Gerhard Gottschalk, and Holger Bruggemann). 12.1 Genomics of Pathogenic Clostridia spp. 12.2 Genomics of Pathogenic Bacilli. 13 The Genomes of Pathogenic Bartonella Species (Carolin Frank, Eva Berglund, and Siv G. E. Andersson). 13.1 Introduction. 13.2 Bartonella Species and Pathogenicity. 13.3 The Bartonella Genomes. 13.4 Genomic Islands and Phages. 13.5 Genomic Islands and Phages in Bartonella Species. 13.6 The Chromosome II-Like Segment in Bartonella. 13.7 B. quintana's Evolution into a Human Pathogen. 13.8 Conclusions and Future Perspectives. 14 Pathogenomics of Gastric and Enterohepatic Helicobacter Species (Sebastian Suerbaum, Sandra Schwarz, and Christine Josenhans). 14.1 Introduction. 14.2 Helicobacter pylori. 14.3 Helicobacter hepaticus. 14.4 Genome Comparisons of Gastric and Enterohepatic Helicobacter Species with Related Bacteria. 14.5 Outlook. 15 Genomics of the Opportunistic Pathogen Legionella pneumophila (Christel Cazalet and Carmen Buchrieser). 15.1 The Genus Legionella: Epidemiology, Life Cycle, and Pathogenesis. 15.2 Genomics of Legionella pneumophila. 15.3 Specific Features of the Legionella Genomes. 15.4 Conclusions. 16 Genomics of Listeria monocytogenes (Michael Kuhn and Werner Goebel). 16.1 Introduction: From Pregenomics to Postgenomics. 16.2 Listeria monocytogenes: A Facultative Intracellular Pathogen. 16.3 Listeria monocytogenes Genetics in the Pregenomic Era: Identification and Characterization of Important Virulence Factors. 16.4 Genome Sequence of L. monocytogenes and Its Comparison with the Closely Related L. innocua. 16.5 Genomic Approaches to Studying the other Members of the Genus Listeria. 16.6 Evolutionary Aspects. 16.7 Identification of Listerial Virulence Factors in the Postgenomic Era. 16.8 Proteomics. 16.9 Transcriptomics. 16.10 Conclusions. III Genomics of Pathogens and Their Hosts: Applications. 17 Genomics of Viruses (Esteban Domingo, Alejandro Brun, Jose Ignacio Nunez, Juan Cristina, Carlos Briones, and Cristina Escarmis). 17.1 Introduction: Wide Scope of Virogenomics. 17.2 Retrieving Information. 17.3 Applications of Data Banks to Virology. 17.4 Beyond Reference Strains: Towards a Second-Generation Virogenomics? 17.5 Virogenomics Through Microarrays. 18 Genomics of Pathogenic Fungi (Gerwald A. Kohler, Alan Kuo, George Newport, and Nina Agabian). 18.1 Introduction. 18.2 Genomics of Primary Fungal Pathogens. 18.3 Genomics of Opportunistic Fungal Pathogens. 18.4 The Tool Box for Functional Genomics. 18.5 Fungal Virulence - From the Genomic Point of View. 18.6 Conclusion. 19 Genomics of Pathogenic Parasites (Gabriele Pradel and Thomas James Templeton). 19.1 Exploring the Genomes of Pathogenic Protozoans. 19.2 The Shaping of the Proteomes of the Pathogenic Protists. 19.3 Role of Horizontal Gene Transfer in Protozoan Genome Plasticity. 19.4 The Apicomplexa. 19.5 The Pathogenic Kinetoplastids. 19.6 The Pathogenic Diplomanad Giardia and the Parabasalid Trichomonas. 19.7 Postgenomic Strategies and the Search for Cure. 20 Model Host Systems: Tools for Comprehensive Analysis of Host-Pathogen Interactions (Michael Steinert and Gernot Glockner). 20.1 Introduction. 20.2 Host-Pathogen Interactions. 20.3 Arabidopsis thaliana: A Plant as a Model for Human Disease. 20.4 Dictyostelium discoideum: Perspectives from a Social Amoeba. 20.5 Caenorhabditis elegans: Answers from a Worm. 20.6 Drosophila melanogaster: A Fruitful Model. 20.7 Danio rerio: Fishing for Knowledge. 20.8 Mus musculus: Of Mice and Men. 20.9 Clean Models and Dirty Reality. 21 Expression Analysis of Human Genes During Infection (Erwin Bohn and Ingo B. Autenrieth). 21.1 Introduction. 21.2 Comparison of Gene Expression Profiles of Macrophages and Dendritic Cells In Vitro Upon Infection with Different Pathogens. 21.3 Septicemia. 21.4 Gene Expression in Epithelial Cells Modulated by Bacteria. 21.5 Common Signatures. 21.6 Genetic Polymorphisms and Mutations Affect Gene Expression: Impact on Infection Susceptibility and Infection Course. 21.7 Concluding Remarks. 22 Pathogenomics: Application and New Diagnostic Tools (Soren Schubert and Jurgen Heesemann). 22.1 Introduction: "In Our Hands". 22.2 Microbiological Diagnostics of Bacterial Pathogens: Aims, Tasks, and Current Limitations. 22.3 The Pregenomic Era: Conventional and Molecular Methods in Microbiological Diagnostics. 22.4 The Postgenomic Era: Use of DNA Microarrays in the Diagnosis of Infectious Diseases in Humans and Animals. 22.5 Microarray Technology in Bacteria: Further Areas of Applications. 22.6 Current Limitations on the Use of DNA Microarrays in Diagnostics in Medical Microbiological Laboratories. 22.7 Final Remarks. 23 The Search for New Antibiotics (Harald Labischinski, Christoph Freiberg, and Heike Brotz-Oesterhelt). 23.1 The Need for Novel Antibiotics. 23.2 Where Will the New Antibiotics Come From? 23.3 Contributions of Genomic Technologies to Antibacterial Research. 23.4 Alternative Approaches in Antibacterial Drug Discovery. 24 Reverse Vaccinology: Revolutionizing the Approach to Vaccine Design (Laura Serino, Mariagrazia Pizza, and Rino Rappuoli). 24.1 Impact of Genomics on Vaccine Design. 24.2 MenB Vaccine Approach by Reverse Vaccinology. 24.3 Following the MenB Experience: Other Pathogens. 24.4 Functional Genomics. 24.5 Gene Expression In Vivo: IVET and STM. 24.6 Transcriptome Analysis and Comparative Genomics. 24.7 Proteomics and Vaccine Design. 24.8 Conclusions. Index.


Best Sellers


Product Details
  • ISBN-13: 9783527312658
  • Binding: Hardback
  • Language: English
  • Sub Title: Genome Analysis of Pathogenic Microbes
  • Width: 186 mm
  • ISBN-10: 352731265X
  • Height: 246 mm
  • Returnable: N
  • Weight: 1284 gr


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Pathogenomics: Genome Analysis of Pathogenic Microbes
-
Pathogenomics: Genome Analysis of Pathogenic Microbes
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Pathogenomics: Genome Analysis of Pathogenic Microbes

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    New Arrivals

    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!