Section 1: Etiology and Pathogenesis
1. Genetics of Inflammatory Bowel Disease
Zhi Wei, Steven Baldassano and Hakon Hakonarson
2. Gut Immunity and Inflammatory Bowel Disease
William A. Faubion
3. Cytokines and Inflammatory Bowel Disease
Edwin F. de Zoeten and Ivan J Fuss
4. The Gut Microbiota and IBD
Judith Kelsen and Gary D. Wu
Section 2: Epidemiology and Clinical Features
5. Epidemiology of Pediatric Inflammatory Bowel Disease
Shehzad Saeed and Subra Kugathasan
6. Early Onset Inflammatory Bowel Disease
Melvin B. Heyman and Neera Gupta
7. The Natural History of Crohn Disease in Children
James F. Markowitz
8. Natural History of Ulcerative Colitis in Children
Jeffrey S. Hyams
9. Natural History of Indeterminate Colitis
Mary K. Rogers Boruta, Richard J. Grand and Michael D. Kappelman
10: Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease
Shervin Rabizadeh and Maria Oliva-Hemker
11. Liver Disease in Pediatric Inflammatory Bowel Disease
Pamela L. Valentino and Binita M. Kamath, MBBChir
12. Growth Impairment in Pediatric Inflammatory Bowel Disease
Thomas D Walters and Anne Griffiths
13. Inflammatory Bowel Diseases and Skeletal Health
Francisco A. Sylvester
14. Puberty and Pediatric-Onset Inflammatory Bowel Disease
Dianne Deplewski and Barbara S. Kirschner
15. Classification of Inflammatory Bowel Disease in Children
Athos Bousvaros
Section 3: Diagnosis
16. The History and Physical Exam
Alka Goyal and David J. Keljo
17. Differential Diagnosis of Inflammatory Bowel Disease
Thierry Lamireau
18. Laboratory Evaluation of Inflammatory Bowel Disease
Jennifer Strople and Benjamin D. Gold
19. Radiologic Evaluation of Pediatric Inflammatory Bowel Disease
Stephen M. Druhan and Benedict C. Nwomeh
20. Endoscopic Modalities in Pediatric Inflammatory Bowel Disease
K Venkatesh and Mike Thomson
21. The Pathology of Chronic Inflammatory Bowel Disease
Pierre Russo
22. Videocapsule Endoscopy in Inflammatory Bowel Disease
Ernest G. Seidman
23. Bone Health in Pediatric Inflammatory Bowel Disease
Meena Thayu and Edisio Semeao
24. Assessment of Growth and Nutritional Status in Children with Inflammatory Bowel Disease
Babette Zemel
Section 4: Medical Therapy
25. Pharmacogenetics in IBD
Marla C. Dubinsky
26. 5-Aminosalicylate Therapy
Michael Stephens and Alisha M. Mavis
27. Antibiotic Therapy
Howard Kader, Douglas Jacobstein and Adam Paul
28. Nutritional Management of Inflammatory Bowel Disease
Anthony Otley, Andrew S Day and Mary Zachos
29. Probiotic Therapy
David R. Mack
30. Corticosteroids
Johanna C. Escher
31. 6-Mercaptopurine Therapy
Carmen Cuffari
32. Methotrexate
Joel R. Rosh
33. Infliximab Therapy for Pediatric Crohn Disease and Ulcerative Colitis
Ilse Hoffman, Tania Claeys, Severine Vermeire, Gert Van Assche, Peter Witters and Paul Rutgeerts
34. Biologic Therapies
Wojciech Blonski, Faten Aberra and Gary R. Lichtenstein
35. Medical Treatment of Perianal Crohn Disease Fistulae
Mark T. Osterman and Gary R. Lichtenstein
36. Management of Fulminant Colitis
Harland Winter
Section 5: Surgical Therapy
37. Surgical Management of Crohn Disease in Children
David von Allmen
38. Surgical Treatment of Ulcerative Colitis
Peter Mattei
39. Pouchitis After Ileal Pouch-Anal Anastomosis
Victor Uko and Robert Wyllie
40. Enteral Feeding Devices and Ostomies
Susan N. Peck
Section 6: Research
41. Clinical Indices for Pediatric Inflammatory Bowel Disease Research
Angela Noble and Dan Turner
42. Clinical Trials (Clinician Perspective)
Salvatore Cucchiara, Giovanni DiNardo and Marina Aloi
43. Clinical Trials (Industry Pers
About the Author:
Petar Mamula, MD
Division of GI, Hepatology and Nutrition, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Jonathan E. Markowitz, MD, MSCE
Greenville Children's Hospital, Pediatric Gastroenterology and Nutrition, University of South Carolina School of Medicine--Greenville, Greenville, SC, USA
Robert N. Baldassano, MD
Division of GI, Hepatology and Nutrition, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
