Pentaerithrityltetranitrat Book by D. Stalleicken
Home > Medicine > Clinical & internal medicine > Musculoskeletal medicine > Pentaerithrityltetranitrat
Pentaerithrityltetranitrat

Pentaerithrityltetranitrat


     0     
5
4
3
2
1



International Edition


About the Book

Organische Nitratester gehören seit über 120 Jahren zum therapeutischen Schatz der pharmakotherapeutischen Behandlung von ischämischen Herz- erkrankungen, insbesondere der koronaren Herzkrankheit (KHK). Sie gehören zu den ersten definierten Wirkstoffverbindungen überhaupt, die in der klini- schen Medizin angewendet wurden. Die Ansichten zu ihrer Wirksamkeit gehen seit genauso langer Zeit auseinander, obwohl der therapeutische Nutzen immer wieder - so auch in jüngster Zeit - beschrieben wurde und ihr Stellenwert in nationalen und internationalen Leitlinien definiert ist. Die kritische Diskussi- on wird im Wesentlichen durch zwei Gesichtspunkte stimuliert, die den klini- schen Einsatz von Nitrovasodilatatoren limitieren. Eine chronische Therapie mit dem am häufigsten untersuchten Glyceroltrinitrat (GTN) führt zu Wir- kungsabschwächung (Toleranz). Auf Grund neuerer Befunde ist dieses Phäno- men der Toleranz die Folge der durch GTN stimulierten verstärkten Bildung von Sauerstoffradikalen, die die NO-Bioverfügbarkeit vermindern und den Prozess der Atherogenese fördern. Für die Compliance des Patienten ist der mit der Therapie verbundene Nitratkopfschmerz ein ausgesprochen negativer Faktor. Die mit GTN erhobenen Befunde wurden in der Vergangenheit und werden auch heute noch immer wieder auf die gesamte Klasse übertragen. Dies ist, wie die Erfahrung mit anderen Substanzklassen (z. B. Ca-Antagonisten und Betarezeptoren-Blockern) eindeutig gezeigt hat, nicht nur wissenschaft- lich unzulässig, sondern auch ausgesprochen problematisch. Für den NO-Donor Pentaerithrityltetranitrat (PETN) konnte insbesondere im vergangenen Jahrzehnt durch methodisch einwandfreie Untersuchungen nachgewiesen werden, dass PETN weder im Tierexperiment noch unter hu- manpharmakologischen Bedingungen hämodynamische Toleranz auslöst. PETN führt auch nicht zu einer vermehrten Bildung von Sauerstoffradikalen. Daher bleibt die NO-Bioverfügbarkeit unter PETN ungestört erhalten.


Best Sellers



Product Details
  • ISBN-13: 9783798514898
  • Publisher: Steinkopff Darmstadt
  • Binding: Paperback
  • Height: 244 mm
  • No of Pages: 128
  • Spine Width: 7 mm
  • Weight: 281 gr
  • ISBN-10: 3798514895
  • Publisher Date: 02 Dec 2004
  • Edition: Softcover Reprint of the Origi ed.
  • Language: German
  • Returnable: N
  • Sub Title: Evidenzorientiertes Therapiekonzept Kardialer Erkrankungen
  • Width: 170 mm


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Pentaerithrityltetranitrat
Steinkopff Darmstadt -
Pentaerithrityltetranitrat
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Pentaerithrityltetranitrat

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    New Arrivals



    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!