1. Chemical Probe Development Versus Drug Development
Michael R. Jackson
2. Phosphatase High-Throughput Screening Assay Design and Selection
Eduard A. Sergienko
3. Multisystemic Functions of Alkaline Phosphatases
René Buchet, José Luis Millán, and David Magne
4. Robotic Implementation of Assays: Tissue-Nonspecific Alkaline Phosphatase (TNAP) Case Study
Thomas D.Y. Chung
5. Inhibitors of Tissue-Nonspecific Alkaline Phosphatase (TNAP): From Hits to Leads
Peter Teriete, Anthony B. Pinkerton, and Nicholas D.P. Cosford
6. A Method for Direct Assessment of Tissue-Nonspecific Alkaline Phosphatase (TNAP) Inhibitors in Blood Samples
Eduard Sergienko, Qing Sun, and Chen-Ting Ma
7. Isolation and Characteristics of Matrix Vesicles
René Buchet, Slawomir Pikula, David Magne, and Saïda Mebarek
8. The Use of Tissue-Nonspecific Alkaline Phosphatase (TNAP) and PHOSPHO1 Inhibitors to Affect Mineralization by Cultured Cells
Tina Kiffer-Moreira and Sonoko Narisawa
9. Modulators of Intestinal Alkaline Phosphatase
Ekaterina V. Bobkova, Tina Kiffer-Moreira, and Eduard A. Sergienko
10. New Activity Assays for ENPP1 with Physiological Substrates ATP and ADP
Chen-Ting Ma and Eduard Sergienko
11. Structure of Acid Phosphatases
César L. Araujo and Pirkko T. Vihko
12. Purification of Prostatic Acid Phosphatase (PAP) for Structural and Functional Studies
Annakaisa M. Herrala, Ileana B. Quintero, and Pirkko T. Vihko
13. Protein Tyrosine Phosphatases: Structure, Function, and Implication in Human Disease
Lutz Tautz, David A. Critton, and Stefan Grotegut
14. High-Throughput Screening for Protein Tyrosine Phosphatase Activity Modulators
Lutz Tautz and Eduard A. Sergienko
15. Evaluating Effects of Tyrosine Phosphatase Inhibitors on T Cell Receptor Signaling
Souad Rahmouni, Laurence Delacroix, Wallace H. Liu, and Lutz Tautz
16. Interactor-Guided Dephosphorylation by Protein Phosphatase-1
Shannah Boens, Kathelijne Szekér, Aleyde Van Eynde, and Mathieu Bollen
17. Structure, Regulation, and Pharmacological Modulation of PP2A Phosphatases
Caroline Lambrecht, Dorien Haesen, Ward Sents, Elitsa Ivanova, and Veerle Janssens