Part I Photochemistry and photo-fabrication

Chapter 1 Photochemistry

1-1 Introduction

1-2 Photochemistry

1-2-1 Energy diagram

1-2-2 Electronic structures

1-2-3 Electronic transition

1-2-4 Absorption and excitation spectra

1-2-5 Photochemical reactions

1-2-5-1 Reactions

1-2-5-2 Sensitizer

1-3 Light source

Chapter 2 Photochemical processed materials

2-1 Photochemical processes for polymeric materials

2-1-1 Photo-polymerization

2-1-1-1 Polymerization mechanism

2-1-1-2 Photo-initiators

2-1-1-3 Visible-light initiators

2-1-1-4 Macromolecular photoinitiator

2-1-1-5 Photo-iniferter

2-1-2 Photo-reactive polymers

2-1-2-1 Photo-reactive groups

2-1-2-2 Photo-reactive polymer by polymerization

A Synthetic polymers

B Natural polymers

2-2 Photo-degradation

Chapter 3 Photo-fabrication

3-1 Introduction

3-2 Planar fabrication and 2D structuring

3-2-1 Micro-patterning

3-2-2 Undeformative processing

3-2-3 Additive processing

3.2.3.A Surface modification

"Grafting-to"

"Grafting-from"

Controlled/living grafting

Photo-iniferter graft polymerization

Topological 2D patterning

3.2.3.B Deposition and transfer of biomaterials

Pulsed laser deposition (PLD)

Laser-induced forward transfer (LIFT)

3.2.4 Substrate processing

Photo-ablation

Surface nano-structuring

3-3 3D structure and volume processing

3.3.1 Stereolithography

3.3.2 Ultrafast laser 3D fabrication

3.3.2.A Principle of 3D fabrication by ultrafast laser

3.3.2.B Undeformative 3D fabrication

3.3.2.C Subtractive 3D fabrication

Medical and tissue engineering applications

3D printing of proteins

3.3.2.E Hybrid 3D fabrication

3-4 Conculsions

Part II Applications for diagnostics

Chapter 4 Microarray chips (in vitro diagnosis)

4-1 introduction

4-2 Microarrays for gene analysis

4-3 Microarrays for protein analyses

4-5 Automated Systems

Chapter 5 Clinical Diagnostic Imaging

5-1 Introduction

5-2 Targeting

5-2-1 Targeting methodology for clinical image diagnosis

5-2-2 Contrast agent targeting for clinical image diagnosis

5-2-3 Characteristics of photochemical contrast agent systems

5-3 Carriers used for imaging diagnosis

5-3-2 Dendrimers

5-3-3 Liposomes

5-3-4 Polymeric micelles

5-3-5 Metal nanoparticles

a Quantum dots

b Silica nanoparticles

c Gold nanoparticles

d Iron oxide nanoparticles

5-4 Applications of optical imaging

5-4-1 Categories of optical imaging agents for medical diagnoses

5-4-3 Near-Infrared fluorescence (NIRF) imaging

A Non-targeted contrast agents

B Non-targeted activatable agents

C Targeted agents

D Clinical applications

5-4-5 Raman spectroscopy (surface-enhanced Raman spectroscopy, SERS)

Part III Applications for therapeutics

Chapter 6 Surfac
About the Author: Yoshihiro ItoChief Scientist and DirectorNano Medical Engineering LaboratoryRIKENWako, Japan
Professional ActivitiesJapanese Society of Polymer Sciences（2002-2004: Chairman of Research group for Biomedical Polymers, 2006-present: Director at Kanto Area）Japanese Society for Biomaterials（2001-present: Council）Japanese Association for Animal Cell Technology（1999-2000,2010: Member of Organizing Committee for International Congress, 2009-2010: Council）Association of Combinatorial Bioengineering (2000-present: Secretary)Japanese Biochemical SocietyThe Biophysical Society of JapanThe Chemical Society of JapanAmerican Chemical SocietyJapanese Society for Artificial Organs（2011-present: Council）Japan Society of Drug Delivery System (2006-present: Council)Japan Bioindustry AssociationThe Japanese Society for Regenerative Medicine (2010-present: Council)The Society for Biotechnology, Japan (2007-present: Council)
Editorial BoardJournal of BiochemistryBiophysics (Japanese)BiomacromoleculesNanomaterials
Awards2009 The Award of Japanese Society of Biomaterials2012 Fellow, Biomaterials Science and Engineering