Phytopharmaka in Forschung und klinischer Anwendung
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Phytopharmaka in Forschung und klinischer Anwendung

Phytopharmaka in Forschung und klinischer Anwendung

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About the Book

Pflanzliche Arzneimittel sind ein wichtiger Bestandteil der Pharrnakotherapie, sei es in der arztlichen Versorgung des Patienten oder im Rahmen der Selbstmedikation nach fachkompe- tenter Beratung durch den Arzt oder den Apotheker. Sie werden seit der Antike nach dem Prin- zip "Trial and Error" angewandt. Was sich bewiihrte, wurde in den sich sUindig vergroBemden Arzneimittelfundus aufgenommen oder verworfen. Der Fortschreibung und Ausweitung lag selten wissenschaftliches Erkenntnismaterial zugrunde. Bei diesen traditionellen Arzneimit- teln handelte es sich meist urn praktische Erfahrungen und Beobachtungen, die von Generati- on zu Generation mlindlich oder schriftlich weitergereicht wurden. 1m Arzneimittelgesetz ( 3 Abs. 2 AMG II) sind Phytopharrnaka definiert als Stoffe aus "Pflanzen, Pflanzenteilen und Pflanzenbestandteilen in bearbeitetem oder unbearbeitetem Zustand". Phytopharrnaka unterliegen wie aile Arzneimittel der Zulassungspflicht, d. h. dem Nachweis der Qualitat, Wirksamkeit und Unbedenklichkeit. Mit der 5. AMG-Novelle yom 9. August 1994 hat der Gesetzgeber in den 109 und 109a fur traditionelle Arzneimittel eine Erleichterung im Zulassungsverfahren geschaffen. Von diesen auBerhalb der Apotheke frei- verkauflichen bzw. freiverkauflichen undloder apothekenpflichtigen traditionellen Phytophar- maka sind die Phytopharmaka abzugrenzen, welche einen hoheren Indikationsanspruch for- demo Mit Recht sind an diese rationalen Phytopharrnaka die gleichen Anforderungen zu stel- len wie an chemisch-synthetische Arzneimittel. Hierzu gehoren wissenschaftliches Erkennt- nismaterial zum pharmakologischen Wirkprofil, soweit moglich zur Pharrnakokinetik, zur Toxikologie und klinische Studien zum beanspruchten Anwendungsgebiet. Der Rlickblick zur Phytopharmakaforschung zeigt, daB die pharmakologische Grundlagen- forschung in den letzten Jahrzehnten vorrangig bei den Herstellerfirmen betrieben wurde.

Table of Contents:
I. Phytopharmaka in der Forschung, Pharmakologie und Wirkungsmechanismus.- Crataegi folium cum flore.- Neuroprotektive Wirkungen des Ginkgo-biloba-Extrakts und seiner Inhaltsstoffe.- Pharmakologische Untersuchungen zur zentralnervösen Wirkung und zum Wirkungsmechanismus der Kava-Droge (Piper methysticum Forst) und ihrer kristallinen Inhaltsstoffe.- Pharmakologische Untersuchungen zur antidepressiven Wirkung von Hypericum perforatum L..- Pharmakologie und Wirkmechanismen von Extrakten aus Sabalfrüchten (Sabal fructus), Brennesselwurzeln (Urticae radix) und Kürbissamen (Cucurbitae peponis semen) bei der Behandlung der benignen Prostatahyperplasie.- Dopaminergic Compounds in Vitex Agnus Castus.- Prolaktinsekretion und Verträglichkeit unter der Behandlung mit einem Agnus-castus-Spezialextrakt (BP 1095E1).- Treatment of Menopausal Symptoms with Extracts of Cimicifuga Racemosa: In vivo and in vitro Evidence for Estrogenic Activity.- Michellamine — Neue antivirale Alkaloide aus afrikanischen Pflanzen.- II. Phytopharmaka in der klinischen Anwendung.- Phytopharmaka in der Onkologie.- Crataegi folium cum flore bei Herzinsuffizienz.- Ginkgo biloba bei Demenzerkrankungen.- Kava-Spezialextrakt: Wirksame Phytotherapie bei Angststörungen.- Johanniskraut als pflanzliches Antidepressivum.- Oleum menthae piperitae: Wirkmechanismen und klinische Effektivität bei Kopfschmerz vom Spannungstyp.- Zusammenfassung und Ausblick.


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Product Details
  • ISBN-13: 9783642854354
  • Publisher: Steinkopff Darmstadt
  • Publisher Imprint: Steinkopff Darmstadt
  • Height: 244 mm
  • No of Pages: 189
  • Width: 170 mm
  • ISBN-10: 3642854354
  • Publisher Date: 07 Jan 2012
  • Binding: Paperback
  • Language: German
  • Returnable: Y


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