1. The Concept of Prenatal Gene Therapy
Charles Coutelle, Simon Waddington
2. Candidate Diseases for Prenatal Gene Therapy
Anna L David, Simon Waddington
3. Vector Systems for Prenatal Gene Therapy: Choosing Vectors for Different Applications
Charles Coutelle, Simon Waddington
4. Vector Systems for Prenatal Gene Therapy: Principles of Adenovirus Design and Production
Raul Alba, Andrew H Baker and Stuart A Nicklin
5. Vector Systems for Prenatal Gene Therapy: Principles of Retrovirus Vector Design and Production
Steven J Howe and Anil Chandrashekran
6. Vector Systems for Prenatal Gene Therapy: Principles of Adeno-Associated Virus Vector Design and Production
Christopher J Binny, Amit C Nathwani
7. Vector Systems for Prenatal Gene Therapy: Principles of Non-viral Vector Design and Production
Suet Ping Wong, Orestis Argyros and Richard P Harbottle
8. Use of Manipulated Stem Cells for Prenatal Therapy
Jessica L. Roybal, Pablo Laje, Jesse D. Vrecenak, Alan W. Flake
9. Animal Models for Prenatal Gene Therapy: Choosing the Right Model
Vedanta Mehta, Donald Peebles, Anna L. David
10. Animal Models for Prenatal Gene Therapy: Rodent Models for Prenatal Gene Therapy
Jessica L. Roybal, Masayuki Endo, Suzanne M.K Buckley, Bronwen R. Herbert, Simon N. Waddington, Alan W. Flake
11. Animal Models for Prenatal Gene Therapy: The Sheep Model
Khalil N. Abi-Nader, Michael Boyd, Alan Flake, Vedanta Mehta, Donald Peebles, Anna L. David
12. Animal Models for Prenatal Gene Therapy: The Non-human Primate Model
Citra N Mattar, Arijit Biswas, Mahesh Choolani, Jerry KY Chan
13. Choice of Surrogate and Physiological Markers for Prenatal Gene Therapy
Juliette Delhove, Ahad A. Rahim, Tristan R. McKay, Simon N. Waddington, Suzanne M.K. Buckley
14. Monitoring for Potential Adverse Effects of Prenatal Gene Therapy: Use of Large Animal Models with Relevance to Human Application
Vedanta Mehta, Khalil N. Abi-Nader, David Carr, Jacqueline Wallace, Charles Coutelle, Simon Waddington, Donald Peebles, Anna L. David
15. Monitoring for Potential Adverse Effects of Prenatal Gene Therapy: Mouse Models for Developmental Aberrations and Inadvertent Germ Line Transmission
Charles Coutellle, Simon Waddington, Michael Themis
16. Monitoring for Potential Adverse Effects of Prenatal Gene Therapy:
Genotoxicity Analysis in vitro and on Small Animal Models ex vivo and in vivo
Michael Themis
17. Risks, Benefits and Ethical, Legal and Societal Considerations for Translation of Prenatal Gene Therapy to Human Application
Charles Coutelle , Richard Ashcroft
1. The Concept of Prenatal Gene Therapy
Charles Coutelle, Simon Waddington
2. Candidate Diseases for Prenatal Gene Therapy
Anna L David, Simon Waddington
3. Vector Systems for Prenatal Gene Therapy: Choosing Vectors for Different Applications
Charles Coutelle, Simon Waddington
4. Vector Systems for Prenatal Gene Therapy: Principles of Adenovirus Design and Production
Raul Alba, Andrew H Baker and Stuart A Nicklin
5. Vector Systems for Prenatal Gene Therapy: Principles of Retrovirus Vector Design and Production
Steven J Howe and Anil Chandrashekran
6. Vector Systems for Prenatal Gene Therapy: Principles of Adeno-Associated Virus Vector Design and Production
7. Vector Systems for Prenatal Gene Therapy: Principles of Non-viral Vector Design and Production
Suet Ping Wong, Orestis Argyros and Richard P Harbottle
8. Use of Manipulated Stem Cells for Prenatal Therapy
Jessica L. Roybal, Pablo Laje, Jesse D. Vrecenak, Alan W. Flake
9. Animal Models for Prenatal Gene Therapy: Choosing the Right Model
Vedanta Mehta, Donald Peebles, Anna L. David
10. Animal Models for
