Recent Advancement in Prodrugs
Drugs used as medicines have many limitations like low chemical stability, aqueous solubility, or oral absorption/bioavailability, rapid presystemic metabolism, toxicity, inadequate site specificity, or poor patient acceptance/compliance (unwanted adverse effects, unacceptable taste or odor, irritation or pain). Prodrugs design is an approach to overcome these limitations.
Key features
- Covers recent advancements in development of prodrugs
- Presents balanced synthesis and applications of prodrug chemistry
- Discusses broad spectrum of prodrug categories and outlines industrial applications
- Reviews prodrugs in cancer nanomedicine, its therapy and treatment
- Elucidates mathematical models to study the kinetics of prodrugs
This book covers recent advances in the design of prodrugs. It contains all the significant recent examples of prodrug chemistry developments and will aid academics and researchers seeking to generate new projects in the field.
About the Author: Dr. Kamal Shah did his graduation from Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal (MP) and also awarded by Chancellor Gold Medal and Smt. Kamla Chaturvedi Memorial Award for securing 1st position in Graduation (B.Pharma). He has qualified GATE 2003 and GATE 2005 (IIT, Mumbai). In the year 2006, He did his Masters from Dr. H.S. Gour University Sagar and worked on method development for determination of pharmacological active components by UV and HPLC. He has completed his doctorate from Dr. APJ Abdul Kalam Technical University, Lucknow. Currently he is working as Associate Professor in Institute of Pharmaceutical Research, GLA University Mathura (U.P.). He has published his research work in various journals of national and international repute, and has total 30 published research papers to his credit and has more than 300 citations. He is a member of various professional and academic bodies like Association of Pharmaceutical Teachers of India (APTI), Institutional animal ethical committee (IAEC) and Board of Studies (BOS). He is reviewer of various National and International journals like Medicinal Chemistry Research, Pakistan Journal of Pharmaceutical Sciences, Journal of Sexual Medicine, Natural Product Research, African Journal of Pharmacy and Pharmacology, International Journal of Pharmacy and Pharmacology, International Research Journal of Pure and Applied Chemistry, Pharmaceutical Biology and Asian Journal of Pharmaceutics. He has also written 6 chapters and Edited 1 book. His area of interest is "Synthesis and evaluation of prodrugs of NSAIDs".
Durgesh Nandini Chauhan completed her B.Pharm degree in Pharmacy from the Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, India and her M.Pharma (pharmaceutical sciences) in pharmaceutics from Uttar Pradesh Technical University, currently Dr. A.P.J. Abdul Kalam Technical University, Lucknow in 2006. Mrs. Durgesh Nandini Chauhan has 10 years of academic (teaching) experience from Institutes of India in pharmaceutical sciences. She taught subjects as pharmaceutics, pharmacognosy, traditional concepts of medicinal plants, drug-delivery phytochemistry, cosmetic technology, pharmaceutical engineering, pharmaceutical packaging, quality assurance, dosage form designing and anatomy and physiology. She is member of Association of Pharmaceutical Teachers of India, SILAE: Società Italo-Latinoamericana di Etnomedicina (The Scientific Network on Ethnomedicine, Italy), and so forth. Her previous research work included "Penetration Enhancement Studies on Organogel of Oxytetracycline HCL." She also attended AICTE-sponsored Staff Development Program on "Effects of Teaching and Learning Skills in Pharmacy-Tool for Improvement of Young Pharmacy Teachers" and workshop on Analytical Instruments. She has written more than 10 publications in national and international journals, 13 book chapters, and authored in 4 books .She is also active as a reviewer for several international scientific journals and active participant in national and international conferences such as Bhartiya Vigyan Sammelan and International Convention of Society of Pharmacognosy. Presently she joined Ishita Research Organization, Raipur, India as a freelance writer and guiding pharmacy, Ayurvedic and science students in their research projects.
Dr. Nagendra Singh Chauhan obtained his M.Pharm, Ph.D from Department of Pharmaceutical sciences, Dr. H.S. Gour University, Sagar in 2006 and 2011. He has around 14 years of research experience. He is presently working as Senior Scientific Officer Grade-II and Government Analyst at Drugs Testing Laboratory avam Anusandhan Kendra, Raipur, Chhattisgarh, India . He has professional Expertise in Natural Product Isolation. Hands on in various techniques like extraction, isolation, and purification of natural products from plant extracts using various chromatographic techniques for separation of compounds includes column, LC-MS, chromatography, prep. TLC, Structure Elucidation Elucidation of structure of Natural Product with the help of various techniques like UV, Mass, IR and NMR. Biological experiments: Well versed with the design, conduct and data treatment of various in vivo experiments like Aphrodisiac, antidiabetic, antistress, hairgrowth, BPH, hepatoprotective Reproductive parameters. He has written more than 50 articles published in national and international journals, 25 book chapters. He has citations more than 1400 with h-index 21 and i10 index of 32 (Google scholar) and scopus h-index 15; 669 citations. He is a member of various professional and academic bodies like Society of Pharmacognosy, International Natural Product Sciences Taskforce (INPST) society, SILAE: Società Italo-Latinoamericana di Etnomedicina (The Scientific Network on Ethnomedicine, Italy), Institutional Human ethical committee, Association of Pharmaceutical Teachers of India (APTI).
Prof. Pradeep Mishra has 42 years of experience in teaching Undergraduate and Post graduate classes in Pharmacy. Out of which 31 years have been with the Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar (MP). He has done B.Pharm., M.Pharm. and PhD from Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar (MP). During this period have been guided 41 students for M.Pharm. and 18 students for Ph.D. Around 110 research papers have been published in various Indian and International journals. During his stay at Sagar, he shouldered the additional responsibilities of the Dean, Faculty of Technology. He has been invited to Chair Medicinal Chemistry/Pharmaceutical Analysis section of Indian Pharmaceutical congress (IPC) held at New Delhi, Pune, Indore and Varanasi. His name is in Panel of referees for a number of Journals. A few of them are Journal of Indian Chemical Society, Indian Journal of Pharmaceutical Sciences, Indian Journal of Natural Products and Journal of Scientific and Industrial Research. On, May 2006, he took up the responsibility of nurturing Institute of Pharmaceutical Research, GLA University, Mathura (UP) as Director/Principal. Currently he is working here as Director of Institute. He has been awarded M.L. Khurana, IJPS Best paper award in 2006. (Hydrolysis kinetics studies of mutual prodrugs of ibuprofen, AV Bhosale, GP Agrawal, P Mishra, Year 2004, Volume 66, Issue: 5, Page: 626-630.) He is Fellow, Institution of Chemists, Calcutta, Indian Chemical Society, Calcutta, Life Member, Indian Society for Technical Education, New Delhi, Life Member, Association of Pharmaceutical Teachers of India (MP/LM018), Member, Indian Pharmaceutical Association, Bombay and Member, Pharmaceutical Society, Dr. Harisingh Gour Vishwavidyalaya, Sagar. Always he worked to improve the quality of teaching and learning. Though he has degree in Pharmaceutical Chemistry, he has developed interest in the subject of Pharmaceutical Analysis. The subject has great importance so far as industry, teaching and research in pharmacy is concerned. he tried his level best to initiate a number of students to work in this branch for their project works. A number of such projects have been published in research journals.
