Role of alpha-synuclein and parkin in dopamine toxicity on SHSY5Y cells - Implications for sporadic parkinson's disease
Home > General > Role of alpha-synuclein and parkin in dopamine toxicity on SHSY5Y cells - Implications for sporadic parkinson's disease
Role of alpha-synuclein and parkin in dopamine toxicity on SHSY5Y cells - Implications for sporadic parkinson's disease

Role of alpha-synuclein and parkin in dopamine toxicity on SHSY5Y cells - Implications for sporadic parkinson's disease


     0     
5
4
3
2
1



Out of Stock


Notify me when this book is in stock
About the Book

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by severe motor symptoms including uncontrollable tremor, postural imbalance, slowness of movement and rigidity [Lotharius and Brundin, 2002]. With the increase in lifespan of the general population there is a subsequent increase in the incidence and prevalence of this disease and it is becoming a significant socio-economic burden globally [Dowding et al., 2006].

Parkinson's disease manifests in both familial and sporadic forms. Familial forms of the disease results from mutations in various PD related genes, the most notable ones being α-synuclein and parkin. However, the steps from mutant gene to neurodegeneration is just beginning to be elucidated. The cause of sporadic PD which arises spontaneously is still not clear. A complex interplay between genetic and environmental factors seems to be responsible for the sporadic cases of PD [Kruger et al., 2002; Lansbury and Brice, 2002].

The major pathological hallmark of this disease is the loss of dopaminergic neurons in the substantia nigra which project into the striatum and results in a severe depletion of neurons in the striatum. Additional neuronal systems, including other catecholaminergic nuclei are also affected in the process [Lotharius and Brundin, 2002].

PD progression involves six neuropathological stages marked by the continuous development of Lewy bodies and Lewy neurites [Braak et al., 2004]. These intraneuronal inclusion bodies are mainly comprised of aggregations of the misfolded protein α-synuclein [Spillantini et al., 1997]. Among the several biochemical abnormalities associated with PD, mitochondrial.


Best Sellers



Product Details
  • ISBN-13: 9781805251453
  • Publisher: Independent Author
  • Binding: Paperback
  • Language: English
  • Spine Width: 6 mm
  • Width: 152 mm
  • ISBN-10: 1805251457
  • Publisher Date: 21 Mar 2023
  • Height: 229 mm
  • No of Pages: 106
  • Weight: 218 gr


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Role of alpha-synuclein and parkin in dopamine toxicity on SHSY5Y cells - Implications for sporadic parkinson's disease
Independent Author -
Role of alpha-synuclein and parkin in dopamine toxicity on SHSY5Y cells - Implications for sporadic parkinson's disease
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Role of alpha-synuclein and parkin in dopamine toxicity on SHSY5Y cells - Implications for sporadic parkinson's disease

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    New Arrivals



    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!