Role of Intermediate and Low Penetrance Genes in Breast Cancer
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Role of Intermediate and Low Penetrance Genes in Breast Cancer

Role of Intermediate and Low Penetrance Genes in Breast Cancer


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About the Book

The FHIT and Caveolin-1 genes are considered to be the intermediate penetrator genes that are involved in the development of Breast cancer. The basic aims of this thesis were to study the role of FHIT and CAV-1 gene in the development and progression of Breast cancer. The main aims of the study are:  Detection of genetic aberrations in different exons of FHIT gene in Breast cancer patients using PCR- SSCP technique.  Confirmation of detected mutations by Automated DNA Sequencing.  Detection of genetic aberrations in different exons of CAV-1 gene and in Breast cancer patients using PCR- SSCP technique.  Confirmation of detected mutations by Automated DNA Sequencing.  Methylation Analysis of different exons of FHIT gene in Breast cancer patients using Standard PCR based Methylation Assays.  Methylation Analysis of different exons of CAV-1 gene in Breast cancer patients using Standard PCR based Methylation Assays.  Restriction fragment length polymorphism of ATM IVS10-6T→G in Breast cancer patients.  Mutational detection of CHEK2 1100delC and NBS1 657del5 by Allele Specific Polymerase Reaction.


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Product Details
  • ISBN-13: 9783838364810
  • Publisher: Lap Lambert Academic Publishing
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Spine Width: 18 mm
  • Width: 152 mm
  • ISBN-10: 3838364813
  • Publisher Date: 20 Jan 2011
  • Height: 229 mm
  • No of Pages: 316
  • Series Title: English
  • Weight: 512 gr


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Role of Intermediate and Low Penetrance Genes in Breast Cancer
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Role of Intermediate and Low Penetrance Genes in Breast Cancer
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