A Sericina da Seda como composto neuroprotector contra a doença de Alzheimer no rato
A Sericina da Seda como composto neuroprotector contra a doença de Alzheimer no rato

A Sericina da Seda como composto neuroprotector contra a doença de Alzheimer no rato


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About the Book

Este livro trata da indução da doença de Alzheimer (DA) no modelo do rato e da extração da proteína da seda, a sericina dos casulos de seda. As experiências centraram-se em estudos morfométricos, comportamentais e bioquímicos, nomeadamente o sistema colinérgico, o sistema antioxidante e estudos histopatológicos em regiões seleccionadas do cérebro do rato. Finalmente, os resultados invivos foram correlacionados com a abordagem bioinformática. Os resultados das nossas descobertas revelaram que a proteína da seda e a sericina apresentaram efeitos positivos no peso corporal, nas capacidades de aprendizagem e na memória (cognitiva) em ratos induzidos pela doença de Alzheimer. Foi óbvio que a sericina exerceu propriedades de AChE em ratos induzidos pela DA, elevando os níveis de ACh e inibindo a atividade da AChE em todas as regiões seleccionadas do cérebro do rato. A sericina mostrou atividade antioxidante, aumentando os níveis de SOD, CAT e diminuindo os níveis de GR e MDA no rato induzido pela DA. Os resultados acima referidos foram fortemente apoiados por estudos histológicos e bioinformáticos. Foi óbvio que as alterações induzidas pela doença de Alzheimer foram invertidas com o tratamento de ratos com sericina numa exposição a longo prazo. Por fim, pode concluir-se que a sericina pode atuar como um potencial melhorador cognitivo para o tratamento da doença de Alzheimer.


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Product Details
  • ISBN-13: 9786206423065
  • Publisher: KS Omniscriptum Publishing
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Weight: 326 gr
  • ISBN-10: 6206423069
  • Publisher Date: 05 Sep 2023
  • Height: 229 mm
  • No of Pages: 184
  • Spine Width: 11 mm
  • Width: 152 mm


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A Sericina da Seda como composto neuroprotector contra a doença de Alzheimer no rato
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A Sericina da Seda como composto neuroprotector contra a doença de Alzheimer no rato
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