Dedication...
Preface...
Table of Contents...
Contributing Authors...
1) Overview of Serpins and Their Role in Biological Systems
Alexandra Lucas, Jordan Yaron, Liqiang Zhang, and Sriram Ambadapadi
2) Methods for Determining and Understanding Serpin Structure and Function: X-Ray Crystallography
Brian P. Mahon, and Robert McKenna
3) Serpin Phage Display: Use of a T7 System to Probe Reactive Centre Loop Libraries with Different Serine Proteinases
Lucas R. de Souza, Benjamin M. Scott, Varsha Bhakta, David A. Donkor, Darian L. Perruzza, and William P. Sheffield
4) Kinetic Measurement of Serpin Inhibitory Activity by Real-Time Fluorogenic Biochemical Assay
Jordan R. Yaron, Sriram Ambadapadi, Liqiang Zhang, and Alexandra Lucas
5) Methods for Identifying Virus-Derived Serpins
Masmudur M. Rahman
6) In Vitro Approaches for the Assessment of Serpin Polymerization
Emma L. K. Elliston, David A. Lomas, and James A. Irving
7) Cellular Models for the Serpinopathies
Annamaria Fra, Emanuela D'Acunto, Mattia Laffranchi, and Elena Miranda
8) Binding of Serpins to Immobilized Phospholipids and Phospholipids in Suspension
Felix C. Wahlmüller, Judit Mihaly-Bison, and Margarethe Geiger
9) Viral Serpin Reactive Center Loop (RCL) Peptides: Design and Testing
Liqiang Zhang, Jordan R. Yaron, Sriram Ambadapadi, and Alexandra Lucas
10) In Vivo Analysis of Alpha 1 Antitrypsin Functions in Autoimmune Disease Models
Sihong Song, Yuanqing Lu, and Ahmed S. Elshikha
11) Analysis of In Vivo Serpin Functions in Models of Inflammatory Vascular Disease
Hao Chen, Sriram Ambadapadi, Erbin Dai, Liying Liu, Jordan Yaron, Liqiang Zhang, and Alexandra Lucas
12) In Vivo Analysis of Alpha 1 Antitrypsin Functions in Autoimmune Disease Models
Sihong Song, Yuanqing Lu, and Ahmed S. Elshikha
13) Serpins in Venous Thrombosis and Venous Thrombus Resolution
Subhradip Mukhopadhyay, Tierra A. Johnson, Rajabrata Sarkar, and Toni M. Antalis
14) Next Generation Sequencing Library Preparation for 16S rRNA Microbiome Analysis after Serping Treatment
Juan Ortis-Maldonado, Jordan R. Yaron, Liqiang Zhang, and Alexandra R. Lucas
15) Methods for Assessing Serpins as Neuroprotective Therapeutics
Jacek M. Kwiecien
16) Serpins: Development as Clinical Therapeutics
Alexandra Lucas, Jordan Yaron, Liqiang Zhang, and Grant McFadden
17) Appendix 1
Serine Protease Assays: Measuring the Enzyme Targets for Serpins, Serine Protease Inhibitors
Jovil Kannampuzha, Anatharam Kalya, and Alexandra Lucas
