Signaling Pathways and Molecular Mediators in Metastasis
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Signaling Pathways and Molecular Mediators in Metastasis

Signaling Pathways and Molecular Mediators in Metastasis


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About the Book

Preface.-1. Introduction.I. Local invasion.-2. Reactivation of Epithelial Mesenchymal Transition in Invasive and Metastatic Cancer.-3. Biomechanical ECM Switches and Tumor Metastasis.-4. Moving aggressively: S100A4 and Tumor Invasion.- 5. Shift in TGF-b-induced signaling as culprit for local invasion and dissemination.-6. Role of Rac1-GEF and Dock180 in mediating tyrosine-kinase stimulated glioma invasion.- 7. Impact of tumor hypoxia, Src and Met signaling in the dissemination of tumor cells.II. Homing and colonization at distant sites.-8. Cellular and Molecular Biology of Cancer Cell extravasation.- 9. Role of CXCL12 and CXCR4 in tumor biology and metastasis.-10. Transcription factors Stat5a/b and Stat3 in prostate cancer growth and metastases.-11. Survival and growth of early metastatic foci in the bone: Role of the alpha-receptor for Platelet-Derived Growth Factor.-12. Androgen receptor in regulation of prostate cancer progression and metastasis.- 13. Integrin signaling in angiogenesis and metastatic progression in the brain.-14. Tumor and host determinants of pulmonary metastasis in bladder cancer.-15. The Influence of metastatic breast cancer on the bone microenvironment. Index.


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Product Details
  • ISBN-13: 9789401782586
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Edition: 2012 ed.
  • Language: English
  • Returnable: Y
  • Spine Width: 23 mm
  • Width: 155 mm
  • ISBN-10: 940178258X
  • Publisher Date: 24 Feb 2014
  • Binding: Paperback
  • Height: 229 mm
  • No of Pages: 378
  • Series Title: English
  • Weight: 594 gr


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