Signaling Pathways for Translation by Robert E. Rhoads
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Signaling Pathways for Translation

Signaling Pathways for Translation


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About the Book

The articles in the present volume are by major contributors to our under- standing of signaling pathways affecting protein synthesis. They focus pri- marily on two extracellular anabolic signals, although others are included as well. Insulin is one of the best-studied extracellular regulators of protein syn- thesis. Several of the known pathways for regulation of protein synthesis were elucidated using insulin-dependent systems. Regulation of protein synthesis by amino acids, by contrast, is an emerging field that has recently received a great deal of attention. The dual role of amino acids as substrates for protein syn- thesis and regulators of the overall process has only recently been recognized. Since amino acids serve as precursors for proteins, one might expect that with- holding an essential amino acid would inhibit the elongation phase. Surpris- ingly, research has shown that it is the initiation phase of protein synthesis that is restricted during amino acid starvation. Understanding the mechanisms by which the biosynthesis of proteins is reg- ulated is important for several reasons. Protein synthesis consumes a major portion of the cellular ATP that is generated. Therefore, small changes in protein synthesis can have great consequences for cellular energy metabolism. Translation is also a major site for control of gene expression, since messenger RNAs differ widely in translational efficiency, and changes to the protein syn- thesis machinery can differentially affect recruitment of individual mRNAs.


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Product Details
  • ISBN-13: 9783540417095
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Edition: 2001 ed.
  • Language: English
  • Returnable: Y
  • Spine Width: 17 mm
  • Weight: 508 gr
  • ISBN-10: 3540417095
  • Publisher Date: 17 Jul 2001
  • Binding: Hardback
  • Height: 239 mm
  • No of Pages: 186
  • Series Title: Progress in Molecular and Subcellular Biology
  • Sub Title: Insulin and Nutrients
  • Width: 157 mm


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