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Sistema microparticolato galleggiante

Sistema microparticolato galleggiante


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About the Book

I sistemi a rilascio prolungato sono concepiti per rilasciare il farmaco in vivo con una certa frequenza, in modo da prolungarne il rilascio per aumentarne l'efficacia e la biodisponibilità. I sistemi di rilascio fluttuante dei farmaci (FDDS) sono uno degli approcci che si prevede rimangano galleggianti in modo duraturo sul contenuto gastrico. I vari preparati galleggianti includono microparticelle, microsfere cave, polveri, granuli, compresse, capsule, pillole e film laminati. Le microparticelle galleggianti sono sistemi di somministrazione di farmaci galleggianti gastro-ritentivi basati su un approccio non effervescente. Le microparticelle galleggianti sono oggetto di particolare attenzione per la loro ampia applicabilità nel targeting dei farmaci nello stomaco. Queste microparticelle fluttuanti hanno il vantaggio di rimanere galleggianti e di distribuirsi uniformemente nel fluido gastrico, evitando i capricci dello svuotamento gastrico e rilasciando il farmaco per un periodo di tempo prolungato. Un sistema a rilascio prolungato con un tempo di permanenza nello stomaco può essere di grande importanza pratica per i farmaci con una finestra di assorbimento nella parte superiore dell'intestino tenue. Le particelle multiparticolate a bassa densità possono prolungare con successo il tempo di ritenzione gastrica del farmaco.


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Product Details
  • ISBN-13: 9786205850091
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Edizioni Sapienza
  • Height: 229 mm
  • No of Pages: 60
  • Spine Width: 4 mm
  • Weight: 150 gr
  • ISBN-10: 6205850095
  • Publisher Date: 01 Apr 2023
  • Binding: Paperback
  • Language: Italian
  • Returnable: N
  • Sub Title: Un approccio per la gastro-ritenzione di farmaci
  • Width: 152 mm


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