Sostanze fitochimiche come inibitori di glucosidasi e amilasi
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Sostanze fitochimiche come inibitori di glucosidasi e amilasi

Sostanze fitochimiche come inibitori di glucosidasi e amilasi


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About the Book

Nel presente studio, diversi campioni vegetali sono stati estratti in diversi solventi in base alla loro polarità. Gli estratti ottenuti sono stati successivamente sottoposti a screening per il potenziale inibitorio dell'α-amilasi. Gli estratti con potenziale inibitorio dell'α-amilasi sono stati successivamente esaminati per la profilazione TLC che ha rivelato diversi modelli di bande di fitocostituenti. Gli estratti esaminati dopo la TLC-Autografia sono stati poi testati per la presenza di sostanze fitochimiche come proteine, carboidrati, fenoli e tannini, flavonoidi, saponine, glicosidi, steroidi, terpenoidi, alcaloidi, filobatannini, oli fissi e acidi grassi. Successivamente, gli estratti pos sono stati caratterizzati mediante HRLC-MS che ha rivelato la presenza di circa 275 composti. I composti ottenuti sono stati poi sottoposti a screening per la regola Lipinski dei cinque che ha rivelato 116 composti che soddisfano tutte e cinque le regole. L'analisi in silico di tutti i 116 composti per l'inibizione dell'α-amilasi e dell'α-glucosidasi ha mostrato un potenziale inibitorio più o meno elevato, dove abbiamo trovato 15 composti che hanno mostrato energie di legame inferiori a -10 kcal/mol. Il lavoro attuale è incentrato sulle sostanze fitochimiche e sulla loro interazione con gli inibitori della glucosidasi e dell'amilasi come potenziali agenti antidiabetici.


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Product Details
  • ISBN-13: 9786207572663
  • Publisher: KS Omniscriptum Publishing
  • Binding: Paperback
  • Language: Italian
  • Returnable: N
  • Weight: 218 gr
  • ISBN-10: 6207572661
  • Publisher Date: 22 May 2024
  • Height: 229 mm
  • No of Pages: 108
  • Spine Width: 7 mm
  • Width: 152 mm


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Sostanze fitochimiche come inibitori di glucosidasi e amilasi
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