Sourcebook of Models for Biomedical Research

The collection of systems represented in Sourcebook of genomic programs, although this work is certainly well Models for Biomedical Research is an effort to re?ect the represented and indexed. diversity and utility of models that are used in biomedicine. Some models have been omitted due to page limitations That utility is based on the consideration that observations and we have encouraged the authors to use tables and made in particular organisms will provide insight into the ? gures to make comparisons of models so that observations workings of other, more complex, systems. Even the cell not available in primary publications can become useful to cycle in the simple yeast cell has similarities to that in the reader. humans and regulation with similar proteins occurs. We thank Richard Lansing and the staff at Humana for Some models have the advantage that the reproductive, guidance through the publication process. mitotic, development or aging cycles are rapid compared As this book was entering production, we learned of the with those in humans; others are utilized because individual loss of Tom Lanigan, Sr. Tom was a leader and innovator proteins may be studied in an advantageous way and that in scienti?c publishing and a good friend and colleague to have human homologs. Other organisms are facile to grow all in the exploratory enterprise. We dedicate this book to in laboratory settings or lend themselves to convenient analy- his memory. We will miss him greatly.

Table of Contents:
Animal Models for Human Diseases.- Selection of Biomedical Animal Models.- Improved Models for Animal Research.- General Considerations.- The Ethical Basis for Animal Use in Research.- Bibliographic Searching Tools on Disease Models to Locate Alternatives for Animals in Research.- NIH Policies on Sharing of Model Organisms and Related Research Resources.- Databases for Biomedical Animal Resources.- Psychological Enrichment for Animals in Captivity.- Well-Established Models.- Integrated Network Modeling of Molecular and Genetic Interactions.- The Sponge as a Model of Cellular Recognition.- Sea Urchin Embryo.- Caenorhabditis elegans Models of Human Neurodegenerative Diseases.- Zebrafish as a Model for Development.- Zebrafish as a Model for Studying Adult Effects of Challenges to the Embryonic Nervous System.- Modeling Cognitive and Neurodegenerative Disorders in Drosophila melanogaster.- Biomedical Research with Honey Bees.- Establishing and Maintaining a Xenopus laevis Colony for Research Laboratories.- The Chicken as a Model Organism.- Rat Knockout and Mutant Models.- Rodent Genetics, Models, and Genotyping Methods.- The House Mouse in Biomedical Research.- Mouse Model for Alzheimer’s Disease.- Guinea Pigs as Models for Human Cholesterol and Lipoprotein Metabolism.- Reliability of Rodent Models.- The Domestic Cat, Felis catus, as a Model of Hereditary and Infectious Disease.- Swine in Biomedical Research.- The Minipig as an Animal Model in Biomedical Stem Cell Research.- The Nonhuman Primate as a Model for Biomedical Research.- Primates as Models of Behavior in Biomedical Research.- Primate Models for Understanding Brain Mechanisms of Cognitive Behavior.- Models for Specific Purposes.- Animal Models for Eye Diseases and Therapeutics.- Animal Models of Noise-InducedHearing Loss.- Human and Animal Models for the Study of Muscle Pain.- Animal Models of Parkinson’s Disease.- Transgenic Animal Models of Neurodegenerative Diseases.- Animal Models of Nociception and Pain.- Nonmammalian Models for the Study of Pain.- Models of Behavior.- Animal Models of Vascular Development and Endothelial Cell Biology.- Models of Behavior.- Animal Models for Atherosclerosis, Restenosis, and Endovascular Aneurysm Repair.- Transgenic mouse models of HIV-1/AIDS and cardiac performance.- Primate Models for the Assisted Reproductive Technologies and Embryonic Stem Cell Biology.- Rat Models of Polycystic Ovary Syndrome.- Murine Models for Reproduction.- Pig Model to Study Dynamics of Steroids During Ovarian Follicular Growth and Maturation.- Molecular Genetic Approach to Identify Inhibitors of Signal Transduction Pathways.- Yeast as a Model System to Study DNA Damage and DNA Repair.- Human Models of Space Physiology.- Developmental Space Biology of Mammals.- A Practical Approach to Animal Models of Sepsis.- Animal Models in Functional Magnetic Resonance Imaging.- Animal Models in Aging Research.- Gene Targeting in Human Somatic Cells.- Animal Models for Investigating the Causes and Mechanisms of Mammalian Germ Cell Aneuploidy.- Genetic Models of Alzheimer’s Disease.- Rat Models of Experimental Autoimmune Encephalomyelitis.- Animal Models in Virology.- Nonhuman Primate Models for AIDS.- Models of Other Human Diseases.- Use of Congenic Mouse Strains for Candidate Disease Gene Identification in Complex Traits.- Animal Models of Sudden Infant Death Syndrome.- Animal Models of Posttraumatic Stress Disorder.- Animal Models for Studying Fetal Alcohol Syndrome, Alcohol-Related Birth Defects, and Alcohol-Related Neurodevelopmental Disorder.- Modeling Drug andAlcohol Abuse.- Mouse Models for Experimental Cancer Therapy.- Rat Models of Skin Wound Healing.- Animal Models of Prostate Cancer.- Animal Models of Diabetes.- Animal Models of Kidney Diseases.- Animal Models of Multiple Sclerosis.- Canine and Feline Models for Cancer.- Obese Mouse Models.- Study of Polycystic Kidney Disease in the Nematode Caenorhabditis elegans.- Animal Models of Myelofibrosis.- Animal Models for Bone Tissue Engineering Purposes.- Other Tools.- Markov Processes for Biomedical Data Analysis.- Software Tools for Modeling Biomedical Systems.- Developing Websites for Biomedical Research and Training.- Building Virtual Research Communities Using Web Technology.