Chapter-I: Steric and stereoelectronic control of molecular structures and organic reactions
1. Influence of steric effects on structures
2. Influence of stereoelectronic effects on reactions 3. Evaluation of the numerical value of anomeric effect
4. Influence of anomeric effect on conformational preferences
5. Influence of anomeric effect on conformational Reactivities
6. Conformations of mono and dithioacetals
7. Conformations of mono and diazaacetals 8. Antiperiplanar effects arising from C-Si, C-Ge and C-Sn bonds
Chapter-II. Reactions at saturated and unsaturated carbons
1. Inter and intramolecular reactions at saturated carbons
2. Intermolecular reactions of epoxides
3. Intramolecular reactions of epoxides 4. Baldwin's rules for ring closure at saturated and unsaturated Carbons
5. SN2' reaction (reaction at unsaturated carbon)
6. SN2 reactions of cyclopropanes activated by two geminal carbonyl groups
7. Reactions involving consecutive intramolecular SN2 reactions leading to rearrangement 8. Dual activation for skeletal rearrangement
9. Solvolysis with neighbouring group participation 10. Rearrangement originating from oxiranes under Lewis acid conditions
11. Rearrangement via classical vs non-classical carbocations
12. Tandem skeletal changes and polyene cyclization
13. Application of Baldwin's 5-exo-trig cyclization 14. Stereocontrol in multi-cyclisation
15. Reaction at sp carbon
16. Beckman rearrangement
17. Curtius rearrangement
Chapter-III: Diastereoselectivity in organic reactions
1. Cram's model for asymmetric synthesis
2. Anh-Felkin modification of Cram's model for asymmetric synthesis
3. Cieplak's model for diastereoselectivity
4. Houk's transition state and electrostatic models for diastereoselectivity
5. Cation coordination model for diastereoselectivity
Chapter-IV: A(1,2) and A(1,3) strains
1. Introduction
2. A(1,2) strain
3. Stereocontrol in reactions on account of A(1,2) strain
4. A(1,3) strain
5. Stereocontrol in reactions on account of A(1,3) strain
6. A(1,3) strain in amides and its consequences on diastereoselectivity
Chapter-V: The conservation of orbital symmetry (Woodward-Hoffmann rules)
1. Introduction
2. Orbitals and symmetry considerations
0. 2 + 2 reaction
About the Author: Veejendra K. Yadav earned his PhD under the mentorship of Dr. Sukh Dev in 1982. He carried out his postdoctoral research at University of Calgary, Memorial University of Newfoundland, University of Ottawa, and University of Southern California over the years 1983-1990 before joining Indian Institute of Technology Kanpur (IITK) as Assistant Professor in late 1990. Over the years, he rose through ranks and became full Professor in 2001. He has taught both undergraduate and postgraduate students at IITK over the past thirty years, and has remained a popular teacher among the students throughout. His research focuses on development of new reactions with emphasis on the construction of pharmacophores, synthesis of biologically active molecules, computational-cum-experimental investigation of facial selectivity, and computational investigation of reaction mechanisms. He has three international patents and 100 research papers in peer reviewed journals to his credit.
