Synthèse de dérivés d'imidazo-thiadiazole tri-substitués
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Synthèse de dérivés d'imidazo-thiadiazole tri-substitués

Synthèse de dérivés d'imidazo-thiadiazole tri-substitués


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About the Book

Dans cette étude, nous avons synthétisé et évalué quelques nouveaux dérivés tri-substitués de l'imidazo [2, 1-b]- 1,3,4- thiadiazole comprenant des parties coumarine et imidazo [2, 1-b]- 1,3,4- thiadiazole. Nous avons rapporté une série d'analogues de l'imidazo [2, 1-b]- 1,3,4- thiadiazole pour cibler MAPK. Les composés ont été synthétisés par des méthodes conventionnelles et le processus de réaction a été suivi par CCM en utilisant une phase mobile appropriée et les points de fusion des composés synthétisés ont également été déterminés. En outre, les composés synthétisés ont également été caractérisés et confirmés par des spectres IR, 1H-RMN, 13C-RMN et de masse. Deux composés sélectionnés ont été envoyés au NCI pour un dépistage anticancéreux et ont obtenu des résultats pour les deux composés (6a & 6b). Le composé 6a a inhibé différentes lignées cellulaires avec un pourcentage de croissance de 140,30. Le composé 6b a inhibé différentes lignées cellulaires avec un pourcentage de croissance de 54,60. Nous concluons donc que le dérivé imidazo [2, 1-b]- 1,3,4- thiadiazole contenant un groupe thiocynaïde (6a) présente une bonne activité anticancéreuse que le composé imidazo [2, 1-b]- 1,3,4- thiadiazole contenant un groupe amino (6b). Ces résultats pourraient offrir un excellent cadre dans ce domaine qui pourrait conduire à la découverte d'agents anticancéreux puissants.


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Product Details
  • ISBN-13: 9786205086391
  • Publisher: KS Omniscriptum Publishing
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Weight: 172 gr
  • ISBN-10: 6205086395
  • Publisher Date: 18 Aug 2022
  • Height: 229 mm
  • No of Pages: 76
  • Spine Width: 5 mm
  • Width: 152 mm


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