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Systems Metabolic Engineering

(Paperback) | Released: 30 Apr 2017

By: Hal S. Alper (Author) , Hal S. Alper (Editor) (Author) , Hal S Alper (Edited) | Publisher: Humana Press | Publisher Imprint: Humana Press

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About the Book

Part I: Modeling and Simulation Tools

1. Genome-Scale Model Management and Comparison

Stephan Pabinger and Zlatko Trajanoski

2. Automated Genome Annotation and Metabolic Model Reconstruction in the SEED and Model SEED

Scott Devoid, Ross Overbeek, Matthew DeJongh, Veronika Vonstein, Aaron A. Best, and Christopher Henry

3. Metabolic Model Refinement Using Phenotypic Microarray Data

Pratish Gawand, Laurence Yang, William R. Cluett, and Radhakrishnan Mahadevan

4. Linking Genome-Scale Metabolic Modeling and Genome Annotation

Edik M. Blais, Arvind K. Chavali, and Jason A. Papin

5. Resolving Cell Composition through Simple Measurements, Genome-Scale Modeling, and a Genetic Algorithm

Ryan S. Senger and Hadi Nazem-Bokaee

6. A Guide to Integrating Transcriptional Regulatory and Metabolic Networks Using PROM (Probabilistic Regulation of Metabolism)

Evangelos Simeonidis, Sriram Chandrasekaran, and Nathan D. Price

7. Kinetic Modeling of Metabolic Pathways: Application to Serine Biosynthesis

Kieran Smallbone and Natalie J. Stanford

8. Computational Tools for Guided Discovery and Engineering of Metabolic Pathways

Matthew Moura, Linda Broadbelt, and Keith Tyo

9. Retrosynthetic Design of Heterologous Pathways

Pablo Carbonell, Anne-Gaëlle Planson, and Jean-Loup Faulon

Part II: Genome Engineering Tools

10. Customized Optimization of Metabolic Pathways by Combinatorial Transcriptional Engineering

Yongbo Yuan, Jing Du, and Huimin Zhao

11. Adaptive Laboratory Evolution for Strain Engineering

James Winkler, Luis H. Reyes, and Katy C. Kao

12. Trackable Multiplex Recombineering for Gene-Trait Mapping in E. coli

Thomas J. Mansell, Joseph R. Warner, and Ryan T. Gill

Part III: Systems-Level 'Omics Tools

13. Identification of Mutations in Evolved Bacterial Genomes

Liam Royce, Erin Boggess, Tao Jin, Julie Dickerson, and Laura Jarboe

14. Discovery of Post-Transcriptional Regulatory RNAs Using Next Generation Sequencing Technologies

Grant Gelderman and Lydia M. Contreras

15. 13C-based Metabolic Flux Analysis: Fundamentals and Practice

Tae Hoon Yang

16. Nuclear Magnetic Resonance Methods for Metabolic Fluxomics

Shilpa Nargund, Max E. Joffe, Dennis Tran, Vitali Tugarinov, and Ganesh Sriram

17. Using Multiple Tracers for 13C Metabolic Flux Analysis

Maciek R. Antoniewicz

18. Isotopically Nonstationary 13C Metabolic Flux Analysis

Lara J. Jazmin and Jamey D. Young

19. Sample Preparation and Biostatistics for Integrated Genomics Approaches

Hein Stam, Michiel Akeroyd, Hilly Menke, Renger H. Jellema, Fredoen Valianpour, Wilbert H.M. Heijne, Maurien M.A. Olsthoorn, Sabine Metzelaar, Viktor M. Boer, Carlos M.F.M. Ribeiro, Philippe Gaudin, and Cees M.J. Sagt

Part IV: Integrating Large Datasets for Modeling and Engineering Applications

20. Targeted Metabolic Engineering Guided by Computational Analysis of

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Product Details

ISBN-13: 9781493962921
Publisher: Humana Press
Publisher Imprint: Humana Press
Edition: Methods in Molecular Biology
Language: English
Returnable: Y
Spine Width: 25 mm
Weight: 888 gr

ISBN-10: 1493962922
Publisher Date: 30 Apr 2017
Binding: Paperback
Height: 254 mm
No of Pages: 474
Series Title: Methods in Molecular Biology
Sub Title: Methods and Protocols
Width: 178 mm

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