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Systems Pharmacology and Pharmacodynamics

Systems Pharmacology and Pharmacodynamics


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About the Book

Role of Systems Modeling in Regulatory Drug Approval.- Quantitative Systems Pharmacology: Applications and Adoption in Drug Development.- Systems Pharmacology: An Overview.- Discrete dynamic modeling: a network approach for systems pharmacology.- Kinetic Models of Biochemical Signaling Networks.- Mechanistic Models of Physiological Control Systems.- Foundations of Pharmacodynamic Systems Analysis.- Direct, Indirect, and Signal Transduction Response Modeling.- Irreversible Pharmacodynamics.- Feedback Control Indirect Response Models.- Nonlinear Mixed Effects Modeling in Systems Pharmacology.- Detecting Pharmacokinetic and Pharmacodynamic Covariates From High-Dimensional Data.- Multi-Scale Modeling of Drug Action in the Nervous System.- Mechanistic Modeling of Inflammation.- Systems Pharmacology of Tyrosine Kinase Inhibitor-Associated Toxicities.- Translational Modeling of Antibacterial Agents.- Viral Dynamic Modeling of Hepatitis C Virus Infection: Past Successes and Future Challenges.- Using Systems Pharmacology to Advance Oncology Drug Development.- Systems Pharmacology Modeling in Type 2 Diabetes Mellitus.

About the Author: Donald E. Mager is a Professor of Pharmaceutical Sciences at the University at Buffalo, State University of New York. He also served as a Visiting Professor at the University Paris Descartes in January from 2007-2013 and 2016. He currently serves on the Clinical Pharmacology Advisory Committee to the FDA and the Editorial Advisory Boards of several journals. Dr. Mager also serves as an Associate or Consulting Editor at CPT: Pharmacometrics & Systems Pharmacology (CPT: PSP), Journal of Pharmacology & Experimental Therapeutics (JPET), and Pharmacology, Research & Perspectives (PRP). He is a former President of the International Society of Pharmacometrics and is a Fellow and member of the Board of Regents of the American College of Clinical Pharmacology. In addition, he is an expert member of the Board of Pharmaceutical Sciences at FIP and serves on the Scientific Advisory Board to Simcyp. His research focuses on identifying molecular and physiological factors that control the pharmacological properties of various drugs, with a focus on anti-cancer and immunomodulatory agents. He has contributed to 120+ peer-reviewed publications.
Holly H.C. Kimko-SA"> is a senior pharmacometrician in the Global Clinical Pharmacology department at Janssen Research & Development, LLC, Spring House, PA, and Adjunct Associate Professor in the Pharmacy School of Rutgers University, New Jersey. Dr. Kimko is a Janssen Research Fellow and American Association of Pharmaceutical Scientists Fellow. She championed the use of modeling and simulations in drug development at the Center for Drug Development Science at Georgetown University Medical School, Washington, DC in 1995-2002. Trained in biochemistry and pharmacy, Dr. Kimko earned her Ph.D. degree in pharmaceutical sciences from the University at Buffalo, State University of New York. She has published key papers on physiologically-based indirect response modeling and applications of clinical trial simulations and has edited two books on clinical trial simulations. Her research interests include strategic application of modeling and simulation tools in all aspects of drug development and post-approval life cycle management. Among her scientific endeavors is a specialty in pediatric drug development.


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Product Details
  • ISBN-13: 9783319830742
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Height: 234 mm
  • No of Pages: 511
  • Series Title: Aaps Advances in the Pharmaceutical Sciences
  • Weight: 779 gr
  • ISBN-10: 3319830740
  • Publisher Date: 04 Jul 2018
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Spine Width: 27 mm
  • Width: 156 mm


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