Síntese e Avaliação de Novos Derivados de Carbazol
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Síntese e Avaliação de Novos Derivados de Carbazol

Síntese e Avaliação de Novos Derivados de Carbazol


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About the Book

Foi sintetizada uma nova série de derivados de carbazol substituídos. No primeiro passo, o 2-Cloro-9-H-carbazole-3-carbaldeído formou-se através da reação de vielsmeier-Hack na presença de DMF e POCl3. O produto intermédio formado com a ajuda da reação de vielsmeier é posteriormente tratado com uma amina substituída diferente para obter um novo derivado de carbazole fundido com a amina substituída. A estrutura do derivado de carbazole substituído foi identificada por cromatografia de camada fina, FT-IR e 1H NMR. Com a ajuda do modelo de eletrochoque máximo (MES), a potência dos compostos sintetizados foi determinada com base na sua redução de convulsões em diferentes intervalos de tempo. Entre todos os compostos sintetizados, o composto 4e apresentou a atividade anticonvulsiva máxima. O composto 4c e o composto 4f também apresentaram uma melhor atividade anticonvulsiva.


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Product Details
  • ISBN-13: 9786207951598
  • Publisher: KS Omniscriptum Publishing
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Weight: 145 gr
  • ISBN-10: 620795159X
  • Publisher Date: 16 Aug 2024
  • Height: 229 mm
  • No of Pages: 56
  • Spine Width: 3 mm
  • Width: 152 mm


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