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Tabelas de Libertação Estável

Tabelas de Libertação Estável


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International Edition


About the Book

O presente estudo foi realizado para desenvolver comprimidos de libertação prolongada oral de tartarato de metoprolol utilizando formadores naturais de matriz hidrofílica (goma xantana e tragacanto). Os comprimidos de matriz de libertação prolongada de tartarato de metoprolol foram preparados utilizando diferentes proporções de fármacos, goma xantana e tragacanto. A celulose microcristalina (MCC) foi utilizada como diluente. O polímero foi incorporado num sistema de matriz utilizando a técnica de compressão directa. Foram avaliadas diferentes formulações relativamente ao perfil de dissolução em tampão fosfato 900 mL (pH 6,8), solução de HCl 0,1 M e água destilada durante 12 h a 37°C. O aumento da quantidade de polímero (goma xantana) na formulação levou a uma libertação lenta do fármaco. O tratamento cinético mostrou os diferentes modelos matemáticos mais adequados (Zero ordem, Primeira ordem, Higuchiís e Hixson-Crowell). A maioria das formulações de matriz sólida seguiram Higuchi ou a cinética de ordem zero. As formulações F1, F2, F3 e F7, F8, F9 mostraram a linearidade máxima. Os resultados mostraram que a formulação F9 contendo 30% de goma xantana e 10% de goma tragacanto é a mais parecida com a da preparação de referência comercializada.


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Product Details
  • ISBN-13: 9786202978415
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Height: 229 mm
  • No of Pages: 124
  • Spine Width: 7 mm
  • Width: 152 mm
  • ISBN-10: 6202978414
  • Publisher Date: 19 Jan 2021
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Weight: 245 gr


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