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Target Discovery and Validation Reviews and Protocols

Target Discovery and Validation Reviews and Protocols


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About the Book

Target Discovery and Validation: Reviews and Protocols Part I: Emerging strategies for targets and biomarker discovery 1. Main approaches to target discovery and validation Mouldy Sioud 2. Bioinformatics approaches to cancer gene discovery Ramaswamy Narayanan 3. Analysis of gene networks for drug target discovery and validation Seiya Imoto, Yoshinori Tamada, Christopher J. Savoie, and Satoru Miyano 4. Target discovery and validation in pancreatic cancer Robert M. Beaty, Mads Gronborg, Jonathan R. Pollack, and Anirban Maitra 5. Molecular classification of breast tumors: Clinical impact on diagnosis, prognosis, and treatment Therese Sørlie 6. Discovery of differentially expressed genes: Technical considerations Øystein Røsok and Mouldy Sioud 7. Genome-wide screening using siRNA-expression libraries Sahohime Matsumoto, Makoto Miyagishi, Ryozo Nagai, and Kazunari Taira 8. Hammerhead ribozyme-based target discovery Masayuki Sano and Kazunari Taira 9. Production of siRNA and cDNA transfected cell arrays on non-coated chambered coverglass for high content screening microscopy in living cells Holger Erfle and Rainer Pepperkok 10. Transgenic animal models in biomedical research Louise-Marie Houdebine 11. Keratin transgenic and knockout mice: Functional analysis and validation of disease-causing mutations Preethi Vijayaraj, Goran Söhl, and Thomas M. Magin 12. The HUVEC/Matrigel assay - an in vivo assay of human angiogenesis suitable for drug validation Dag K. Skovseth, Axel M. Küchler, and Guttorm Haraldsen 13. A murine model for studying hematopoiesis and immunity in heart failure Per Ole Iversen and Dag R. Sørensen 14. An overview of the immune system and technical advances in tumor antigen discovery Mouldy Sioud 15. Potential target antigens for immunotherapy identified by serological expression cloning(SEREX) Dirk Jäger 16. Identification of tumor antigens using proteomics Françoise Le Naour 17. Protein arrays: a versatile toolbox for target identification and monitoring of patient immune responses Lina Cekaite, Eivind Hovig and Mouldy Sioud 18. Considerations for target validation and industrial approaches Carlos R. Plata-Salamán, and Sergey E. Ilyin


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Product Details
  • ISBN-13: 9781617376993
  • Publisher: Humana Press
  • Publisher Imprint: Humana Press
  • Edition: 1st ed. Softcover of orig. ed. 2007
  • Language: English
  • Returnable: N
  • Spine Width: 21 mm
  • Weight: 589 gr
  • ISBN-10: 161737699X
  • Publisher Date: 19 Nov 2010
  • Binding: Paperback
  • Height: 229 mm
  • No of Pages: 354
  • Series Title: Methods in Molecular Biology
  • Sub Title: Emerging Strategies for Targets and Biomarker Discovery, Volume 1
  • Width: 152 mm


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