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Terapia fotodinámica

Terapia fotodinámica


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About the Book

La terapia fotodinámica (TFD) es un nuevo y prometedor tratamiento de cáncer que emplea la combinación de un fotosensibilizador y la luz visible en presencia de oxígeno. En TFD, la luz visible activa a una droga fotosensibilizadora y produce oxígeno singlete, así también como otras especies reactivas del oxígeno (ROS) que inducen muerte celular y regresión tumoral. Esta terapia gatilla una serie de procesos fotoquímicos y fotobiológicos los cuales resultan involucrados en múltiples vías durante la muerte celular. En este trabajo se estudió el efecto de diferentes metaloporfirinas (TMP, CuTMP, ZnTMP y CdTMP) y metaloftalocianinas (ZnPcOCH3, ZnPcCF3 y ZnPcPC). En estudios "in vitro", ZnPcOCH3, en condiciones de oscuridad no provoca cambios en la supervivencia e induce una pronunciada disminución de la viabilidad celular dependiente de la dosis de luz. Por otra parte los resultados de ZnPcOCH3-TFD mostraron que las células y las mitocondrias fueron modificadas ultraestructuralmente y los lisosomas dañados parcialmente. Este tratamiento " in vivo" produce regresión tumoral del 50, 70 y 100% dependiendo de la dosis de irradiación, encontrándose involucrado el proceso apoptótico.


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Product Details
  • ISBN-13: 9783845488844
  • Publisher: Eae Editorial Academia Espanola
  • Binding: Paperback
  • Language: Spanish
  • Returnable: N
  • Spine Width: 14 mm
  • Weight: 412 gr
  • ISBN-10: 3845488840
  • Publisher Date: 21 Sep 2011
  • Height: 229 mm
  • No of Pages: 244
  • Series Title: Spanish
  • Sub Title: estudios In Vitro e In Vivo
  • Width: 152 mm


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