In this tragedy-written by none other than Shakespeare himself around 1608-Mark Antony (no, not that Marc Anthony) and Cleopatra fall in love. Simple enough, right?
Wrong.
These two aren't your average star-crossed lovers. Oh no. They both rule over two of the most important empires in history: Rome and Ancient Egypt.
The play opens in Cleopatra's palace in Alexandria, Egypt. But as the story continues, Antony's political and social duties take the action to Rome, Syria, Actium, Parthia (modern-day Iraq), Athens, and various military camps throughout Egypt. The thing is, Antony and Cleopatra aren't very good at the whole despot-jetsetter lifestyle and are constantly put in locations and situations where they question each other's loyalty and love.
We won't give away too much, but the fact that this is a tragedy should tell you a lot about how the play ends. The ending serves as yet another example of how passion mingled with power, treachery, and misunderstanding can lead to a tragic end. We see this time and again in Shakespeare's great works.
Antony and Cleopatra constitutes Shakespeare's return to Roman history after an eight-year break. We would need a break too-this stuff gets pretty heavy. It also gives him a chance to explore the theme of Empire, which was a hot topic in England then because it was a good time to run around sticking a flag in any land you could find.
In other words, English colonial holdings were expanding. A big part of that colonial endeavor was making sure other cultures accepted yours as superior. Shakespeare calls this practice into question by pointing out that different cultures had been living successfully before the British arrived. Interestingly, Rome was successful as a conquering nation because it was more likely to let people keep their way of life and just pay a tax to Rome, instead of making them give up their own culture entirely. How the empire tax would be enforced in other nations was still in question, and it almost seems like Shakespeare was giving the people of his time a history lesson, asking them to consider a different way of handling the whole empire issue.
Finally, there's a reference to the future of Christianity in the play. The end of the Roman Empire marks the beginning of the spread of Christianity throughout the world. When Caesar talks about the coming of universal peace, he means his reign, but it's a nod to Shakespeare's Christian audience that Christ brought real universal peace, and saved us modern-day folks from the ills of those ancient cultures. If it hadn't been for Christ, he seems to be saying, we might still be in the constant wars that characterized folks like the Romans or Egyptians. That's right, this play is basically one big "Thank you, Jesus!"
Whether or not you agree with Shakespeare's religious leanings, this play is full of love, adventure, dramatic empresses, and poisonous snakes-what more could you ask for?