Preface
1 Introduction
PART I. TRANSALATION MACHINERY IN CANCER
2 Mechanism of Translation in Eukaryotes
3 Diverse Mechanisms of Translation Regulation and Their Role in Cancer
4 eIF4E and Its Binding Proteins
5 RNA Helicases and Their Cofactors
6 PDCD4
7 eIF4G
8 eIF3
9 The eIF2 Complex and eIF2α
10 eIF5A
11 eIF6
12 Translation Elongation
13 Ribosomes
14 Current and Emerging Therapies Targeting Translation
PART II. REGULATION OF TRANSLATION BY SIGNALING PATHWAYS IN CANCER
15 mTOR and Regulation of Translation
16 Ribosomal Protein S6 and S6 Kinases
17 eIF4E Phosphorylation Downstream of MAPK Pathway
PART III. CELL FATE AND TRANSLATION IN CANCER
18 Translational Control of Cell Proliferation and Viability in Normal and Neoplastic Cells
19 Translation and Apoptosis in Cancer
20 Translation in Cancer at Hypoxia
PART IV. TRANSLATION AND ITS REGULATION BY CANCER TYPES
21 Melanoma and Non-Melanoma Skin Cancers
22 Sarcomas
23 Hematological Malignancies and Premalignant Conditions
24 Brain Tumors 25 Head and Neck Cancers
26 Breast Cancer
27 Cancers of the Respiratory System
28 Gastric and Esophageal Cancers
29 Colorectal Cancers
30 Hepatic, Pancreatic and Biliary Cancers
31 Pancreatic Neuroendocrine Tumors
32 Gynecologic Cancers
33 Prostate Cancer
34 Cancers of the Urinary System
List of Abbreviations
