About the Book
Prelims
I. Molecular Mechanisms
1. Asymmetric Dimethylarginine Accelerates Cellular Senescence
2. Membrane-Derived Extracellular Vesicles from Endothelial Progenitor Cells Activate Angiogenesis
3. Induction of P21-Dependent Senescence: Role of NAE Inhibitor MLN4924
4. Regulation of the Novel Senescence Pathway by SKP2 E3 Ligase
5. Oncogene-Induced Senescence: Role of Mitochondrial Dysfunction
6. Interleukin- 6 induces Premature Senescence Involving Signal Transducer and Activator of Transcription 3 and Insulin-Like Growth Factor-Binding Protein 5
7. A Role for the Nuclear Lamina Shape in Cell Senescence and Aging
8. Upregulation of Alpha-2-Macroglobulin in Replicative Senescence
9. Elevation of Ceramide in Senescence: Role of Sphingolipid Metabolism
10. Molecular Signals Underlying Hair Follicle Morphagenesis and Cutaneous Regeneration
11. Role of Chromatin -Remodeling Factor Jun Dimerization Protein 2 (JDP2) in Cellular Senescence
12. Induction of Cellular Senescence: Role of Mitogen-Activated Protein Kinase-Interacting Kinase 1
13. Mechanisms of Premature Cell Senescence
II. Tumor and Cancer
14. Nuclear Protein Pirin Negates the Cellular Senescence Barrier Against Cancer Development
15. Defects in Chromatin Structure and Diseases
16. The Role of Fibrosis in Tumor Progression and the Dormant to Proliferative Switch
17. Diagnosis of Branchial Cyst Carcinoma: Role of Stem Cells and Dormancy
18. Function of ING Proteins in Cancer and Senescence
19. Premalignancy and Cellular Senescence
20. Loss of CDH1 Triggers Premature Senescence in Part Via Activation of Both the RB/E2F1 and the Claspin/CHK1/P53 Tumor Suppressor Pathways
21. Suppression of Premature Senescence and Promotion of Metastatic Transformation: Role of Reduced TGF-Beta Signaling in Human Cancer Progression
22. Senescence Escape in Melanoma: Role of Spleen Tyrosine Kinase SYK
23. Micrometastatic Cancer Cells: Role of Tumor Dormancy in Non-Small Cell Lung Cancer
III. Quiescent CD4+ T Cells Inhibit Multiples Stages of HIV Infection Stem Cells and Cancer Stem Cells 24. Senescent-Derived Pluripotent Stem Cells are able to Redifferentiate into Fully Rejuvenated Cells
25. The Transcription Factor Gata2 Regulates Quiescence in Haematopoietic Stem and Progenitor Cells
26. Dormancy and Recurrence of Cancer Stem Cells in Bone: Role of Bone Morphogenetic Proteins
27. Role of Microenvironment in Regulating Stem Cell and Tumor Initiating Cancer Cell Behavior and its Potential Therapeutic Implications
Index.
