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Vaccine Efficacy Evaluation

Vaccine Efficacy Evaluation


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About the Book

Testing the immunogenicity, protective efficacy and safety in animal models is a crucial step in vaccine development. Pigs raised in germ-free environments, called gnotobiotic (Gn) pigs, are one of the most useful animal models for testing vaccines. The Gn pig model is a widely accepted model for studying pathogenesis and immunity and an ideal model for pre-clinical testing for the safety and efficacy of enteric viral vaccines. Through these studies and others, the Gn pig model has been established as the most reliable animal model for pre-clinical evaluation of human rotavirus and norovirus vaccines. This book provides detailed information on establishing Gn pig models, determining a proper virus inoculum pool and challenge dose, measuring protection and calculating efficacy, and delineating intestinal and systemic immune responses associated with the protection.

Key Features

  • Provides a natural history of human rotavirus and norovirus infection in Gn pigs
  • Establishes the optimal virus challenge doses in Gn pigs for vaccine evaluation
  • Evaluates various candidate rotavirus and norovirus vaccines
  • Discusses human gut microbiota transplanted Gn pig models
  • Documents the role of probiotics and rice bran as prophylactics and vaccine adjuvants

About the Author:

Lijuan Yuan is a Professor of Virology and Immunology in the Virginia-Maryland Vet Med's Department of Biomedical Sciences & Pathobiology. Dr. Yuan studies the interactions between enteric viruses and the host immune system. Her lab's research interests are focused on the pathogenesis and innate and adaptive immune responses induced by enteric viruses, especially noroviruses and rotaviruses, and on the development of safer and more effective vaccines as well as passive immune prophylaxis and therapeutics against viral gastroenteritis. These studies utilize wild-type, gene knock-out, and human gut microbiota transplanted gnotobiotic pig models of human rotavirus and norovirus infection and diseases and cell culture model of rotavirus infection. Currently, the Yuan lab is evaluating the immunogenicity and protective efficacy of several candidate novel rotavirus and norovirus vaccines and engineered probiotic yeast Saccharomyces boulardii secreting multi-specific single-domain antibodies as novel prophylaxis against both noroviruses and Clostridioides difficile toxins. See: https: //vetmed.vt.edu/people/faculty/yuan-lijuan.html


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Product Details
  • ISBN-13: 9781032234748
  • Publisher: Taylor & Francis Ltd
  • Binding: Hardback
  • Language: English
  • Returnable: N
  • Sub Title: The Gnotobiotic Pig Model
  • Width: 133 mm
  • ISBN-10: 1032234741
  • Publisher Date: 13 Apr 2022
  • Height: 203 mm
  • No of Pages: 189
  • Series Title: Pocket Guides to Biomedical Sciences
  • Weight: 403 gr


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