Curing disease is a monumental task. Yet, the Influenza Virus is about to be eradicated. Hollbech & Mills Pharmaceutical have accomplished the impossible with The Vaccine. Mia Westover discovers the real reason why the cure for Influenza was created. However, an unforeseen mutation is waiting to rear its ugly head, derailing the plans of the pharmaceutical giant. Mia has but one chance to save humanity. Dr. Anthony Mills has covertly bribed his way into the Utah Prison System. He is scheming and pushing his so-called clinical trials upon unsuspecting inmates. Using prisoners as test subjects are welcomed by Warden, Nick Spencer. Troy Backus has been an active team member alongside Dr. Mills in the conception and creation of The Vaccine. Yet, Dr. Anthony Mills, Dr. Richard Wellington, and Dr. Clovis Edwards have skillfully cloaked a hidden secret of The Vaccine from the general public and their own staff. A mutation occurs inside a large, bald-headed inmate, called Mad Cow. His cellmate becomes hysterical and kept repeating how Mad Cow had mutated right in front of him. Yet, he looks normal now. The cell mate described how Mad Cow's entire eyeballs turned yellow. His skin turned a pale blue, and his veins pushed up against the surface of his skin and turned a blackish color. Now, the mutation loose and is satisfying their appetites and wreaking havoc across Utah and the rest of the United States. Borders to the North and South of the United States have been closed up tight by our neighboring countries. Kate and Kyle Marshton are tirelessly working their way to each other. Gathering their children, Ian, Josh, and Kayla from school, in the chaos, is no simple task, as they witness the mutations consume people right before their eyes. Uncle Leo Larsen gathers the Marshton's and their friends like a hen gathers her chicks. But being forced out of their stronghold, Leo aims his family to the more rural parts of Utah. However, fate has a different plan. Mia's step-grandfather is rescued by Kate. Because of Kate's kindness towards Dr. Kurt Stein, he confides in her about the real reason The Vaccine was created. Dr. Kurt Stein places a choice before Kate. She leaps at a single chance to save her family and humanity. A mother would do anything for her children.