Wirkung von phenolischen Verbindungen auf die Produktion von NET's
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Wirkung von phenolischen Verbindungen auf die Produktion von NET's

Wirkung von phenolischen Verbindungen auf die Produktion von NET's


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About the Book

Die extrazellulären Fallen der Neutrophilen (NETs) bestehen aus freigesetzter nukleärer DNA in Verbindung mit Histonen und granulären Proteinen, die eine netzartige extrazelluläre Struktur bilden, die bestimmte Mikroben einfangen und abtöten kann.Nach Erfüllung ihrer Funktion sollten die NETs normalerweise durch DNAse abgebaut werden. Bei schlechter Clearance können NETs jedoch eine wichtige Quelle von Autoantigenen darstellen, was das Risiko einer Autoreaktivität gegen ihre Bestandteile erhöht. Dies erhöht das Risiko für die Entwicklung verschiedener Autoimmunerkrankungen wie rheumatoide Arthritis (RA) und systemischer Lupus erythematodes (SLE) erheblich. Daher scheint die Verwendung von Molekülen mit einem hohen antioxidativen Potenzial ein gangbarer Weg zu sein, um die schädlichen Auswirkungen von NETs auf das Gewebe zu minimieren, insbesondere bei akuten oder chronischen Entzündungen. In unserer Arbeit haben wir die hemmende Wirkung von vier Molekülen, nämlich Oleuropin, Tyrosol, Tyrosol3 und Phenylethanol, auf die Bildung von NETs untersucht.


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Product Details
  • ISBN-13: 9786207250400
  • Publisher: KS Omniscriptum Publishing
  • Binding: Paperback
  • Language: German
  • Returnable: N
  • Weight: 150 gr
  • ISBN-10: 6207250400
  • Publisher Date: 12 Mar 2024
  • Height: 229 mm
  • No of Pages: 60
  • Spine Width: 4 mm
  • Width: 152 mm


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